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Types of Scientific Literature
Peer Reviewed Journal Articles
Abstracts of
of Presentations
Presentations at Scientific
Meetings
Review Articles
Books
The N Y
. . Times
Times, Wall
W
Street Jo rnal
u
and
Newsweek etc. are NOT Scientific
Literature

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Oi
Organi
t
za i
tion of a Journal
Article
Abstract
Introduction
Mt
Me hd
thods
Results
Discussion
Cl
Concl
i
us ons

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Access to Journal Articles
Local Library with Link to Medical Library
O Li
n- ne Service
Individual Journals
Usually have an Archive
Free download for Articles >12 mos. old
Payment for Articles < 12 mos. old
IMF Web Site Link to Articles

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"Multiple Myeloma is an
Incurable Disease"
Start of
of Most
Most Myeloma
Myeloma Papers
Scary Statement
Ignore It
Di b
a
t
e es is an Incurable Disease

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Acronyms & Abbreviations
Used Extensively
Numerous
Generally they are Defined
Defined
Become Familiar with the Most
Common

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A&
Acronyms & Abb
Abbrevi t
a i
tions
EFS
Event Free Survival
OS
Overall Survival
TTP
Ti
Time
me to Progression
SRE
Skeletal Related Event
VGPR
Ve
Very
ry Good Partial Response
Response
DVT
Deep Vein Thrombosis
PSCT
Peripheral Stem Cell Tr
T ansplant
HDT
High Dose Therapy
CR
Complete Resp
pponse

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Study Methodology
Patient Inclusion Criteria
Treatment Protocol
Tt
Tests to be Performed
Outcome Measurements
Measurements

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Statistics
Tx Overall Survival (OS) Months
Mean Median
A
35, 40, 50, 51, 60, 62, 84
54.6
51
B
26, 38, 40, 45, 55, 80, 96
54.2
45
C
27, 37, 51, 62, 66, 70, 78
55.8
62

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Overall Survival Distribution
/
s
y
e
Tt
Treatment D
encu rrenc
Freq
ccuO
0
50
100
150
200
Overall Survival (Months)

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I t
n erpreting St ti
a stics
Al
App ilicabl
ble only to th
the Specifi
ific
Study
Necessary to Critically Compare
Diff
Dif erent
f
Tr
T eatments
r
Does not Apply to an Individual
Patient
Many patients live in
in the
the tail

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Define Your Purpose
Newly Diagnosed
Relapse/Refractory
Autologous Stem Cell Transp
gplant
Allogeneic Transplant
Specific DrugTreatment
Cytogenetic Abnormality

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Recommendations
Read as Much as You Can
Keep Everything You Read in
Perspective
These Studies do NOT Apply to an
Individual Patient
These studies Can be Useful for
Tt
Treat
t
men Pl
Planning

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