Use of Lenalidomide (Revlimid®) +/-
Corticosteroids in
Relapsed/Refractory Multiple Myeloma
Patients with
Elevated Baseline Serum Creatinine Levels
Donna E Reece, MD1, Esther Masih-Khan, PhD1*, Christine Chen, MD1,
Lisa Wang1*, Saima Dean1*, Vishal Kukreti, MD1, Joseph R Mikhael, MD1,
Suzanne Trudel, MD1, Robert Knight, MD2 and Jerome Zeldis, MD2.
1Princess Margaret Hospital, University Health Network,
Toronto, Ontario, Canada, M5G 2M9 and
2Celgene Corporation, Summit, NJ, United States, 07901.

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Summary and Conclusions
· Patients with elevated cr levels were more often male
and had lower baseline platelet counts.
· After 3 cycles, almost half (45%) with an elevated
baseline cr level experienced a decrease in cr level,
which normalized in 29%.
· Although 7 patients(29%) with an elevated baseline
cr level experienced an increase in cr level, this was
minimal and clinically insignificant.
· The incidence in grade 3-4 neutropenia, febrile
neutropenia or any infection was similar in both
groups.

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Summary and Conclusions
(continued)
· Patients with an elevated baseline cr level
experienced more grade 3-4 thrombocytopenia and
more often required platelet transfusions (67% vs
28%). However, no bleeding complications were
observed in this group.
· The response rate, progression-free survival and
overall survival are similar to date in patients with an
elevated or normal baseline cr level.

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