Step 10: Clinical Trials: Gaining Access to
New Drugs
New options
Key Information
Variables
available but
·Phase II or III trials
·Age
approved options
available
·Medical issues
also available
·Risk factors
·Prior responses
No approved options
Key Information
·Costs
feasible or available
·Phase I/II/III trials
·Preference
available

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Types of New Drug Trials
Phase I
Safety
Phase II
Response

Longer
Single Agent
(Relapsed Refractory)
Phase III
Term
·Response
Benefit
Randomized
(1-3 Relapses)
Randomized against "accepted
·Response
comparator*"
·PFS
(e.g. Revlimid/Velcade...)
·Survival

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Step 10: Strategies in Selecting a Clinical
Trial
Clinical trial
available
Strategic Planning
·Discuss new protocols vs.
approved options
·Assess eligibility
·Clarify expectations, testing
required, duration of study
Current New Drug Options
and other details
·Carfilzomib
·Consider short/long term
·Pomalidomide
logistics
·Elotuzumab
·Consider cost/insurance
·Vorinostat or related
·Discuss preference with
·Check Matrix and/or call Hotline
family/friends
for current details.

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