/var/www/vhosts/myeloma.org/httpdocs/spider

2004-2005

International Myeloma Foundation-----IMF

......

""""
"""
"""

"
"Monoclonal Gammopathy of Undetermined Significance---MGUS
""MGUS 1%
10-30%"/"
MGUS""

MGUS

----------------------------------------------------------------------------------------------------------------------
MGUS
MGUS

----------------------------------------------------------------------------------------------------------------------

MGUS

CRAB

----------------------------------------------------------------------------------------------------------------------
C----->10mg/L
R----->2mg/L
A-----(<10g/dL)
B-----()

,
HIV-8

5-10%
15,000
0.5-1/100,000 10-12/100,000

/

""

""
""

/

-------------------------------------------------------------------------------------------------------------------------------

-------------------------------------------------------------------------------------------------------------------------------

-------------------------------------------------------------------------------------------------------------------------------
/

-------------------------------------------------------------------------------------------------------------------------------

----------------------------------------------------------------------------------------------------------------------------

----------------------------------------------------------------------------------------------------------------------------

GADE M 65% IgG
G IgAIgMIgA IgE
30% 10%
""
1-2%"
" Freelite

-------------------------------------------------------------------------------------------------------

IgG
KappaLambda
IgG IgG
-------------------------------------------------------------------------------
IgA
KappaLambda
IgA IgA
IgDIgE IgM

IgG IgA
IgD

""/
""

Durie Salmon

-------------------------------------------------------------------------------
I

6,000
<10g/dl
<10.5mg/dl
X 0

M-
IgG <5g/dl
IgA <3g/dl
<4g/24
----------------------------------------------------------------------------------------------------------------------
II
I , III
6,000-12,000
----------------------------------------------------------------------------------------------------------------------
III

>12,000
<8g/dl
>12mg/dl

(3 )
M-
IgG >7g/dl
IgA >5g/dl
>12g/24

A<2.0mg/dl
B(2.0mg/ dl)
I A
III B
""

-------------------------------------------------------------------------------------------------------------------
S2M

S.Alb

C CRP

LDH

FISH
#13

UPEP

FREELITE
----------------------------------------------------------------------------------------------------------------------

X
X X

/
MRI
X //
X

/
CT
X /

FDG/PET

-------------------------------------------------------------------------------------------------------------

"
"

---------------------------------------------------------------------------------------------------------------------

----------------------------------------------------------------------------------------------------------------------

,

()
----------------------------------------------------------------------------------------------------------------------

,

/
----------------------------------------------------------------------------------------------------------------------

,

----------------------------------------------------------------------------------------------------------------------

*

----------------------------------------------------------------------------------------------------------------------
*.

//

*?
*?
*?
*?
*?
*
*""
*""
*
""
*
.

-------------------------------------------------------------------------------------------------------

Dexamethasone
70%

Thalidomide

----------------------------------------------------------------------------------------------------------------------
Dexamethasone
VAD

----------------------------------------------------------------------------------------------------------------------
MPMelphalan/

Predisone

60%

/

----------------------------------------------------------------------------------------------------------------------
VADVincristin/
70%

Adriamycin/

Dexamethasone

Vincristin
----------------------------------------------------------------------------------------------------------------------
VELCADE

Dexamethasone

----------------------------------------------------------------------------------------------------------------------
Cytoxan

Cyclophosphanide

EtoposideVP-

16

VBMCPM2
VMCPVBAPSWOG
ABCMUK MRC
CVAD

----------------------------------------------------------------------------------------------------------------------

----------------------------------------------------------------------------------------------------------------------
·

·

----------------------------------------------------------------------------------------------------------------------

· 9 Aredia 90mg
2-4

Zometa
4mg

15-45

· Tylenol

Fentanyl

----------------------------------------------------------------------------------------------------------------------

·

· Neurogen

·
·

""
C(>100 /)

.
.../

,
www.myeloma.org IMF800-452-CURE

,

1..
·

·
·
·?

·
·
2.
·?
·?
·
·?
·

·
3.""

·

·
4.
·,.

·""""
·""""

""

/
""
""""

Accrual- --:

Acute--
Alkylating Agent--- melphalan(),cyclophosphamide(
) DNA
Allogeneic---"Transplantation"
Amyloidosis--()
Lambda Kappa

Analgesic--- Aspirin acetaminophen
Analog---
Anemia--- 10g/dl 13-14g/dl

Anesthesia ---

Angiogenesis---
Angiogenesis inhibitors---
Antibiotics---
Antibody---

""

Antiemetic agent---
Antifungal agent---
Antigen---

Antineoplastic Agent---
Appendicular skeleton---

Apoptosis---
Aspiration---
Asymptomatic myeloma---""
""
""
Axial Skeleton---
B cells---B B-
Basophil---

Bence Jones--- 24
<0.1g/24h

Benign--- MGUS

Beta 2 Microglobulin2M---2
/ 10%2
2M
90%2M
Biopsy---
Bisphosphonate---

Blood cells---
Blood count---
Bone marrow---
Bone marrow aspiration---
Bone marrow biopsy---

Bone remodeling---

BUNBlood Urea Nitrogen---BUN
BUN

Calcium---
Cancer---

Carcinogen---
CATComputerized Axial Tomographyscan--- X-
CT
Catheter---

Cell---
Cell differentiation---

Cell proliferation---
Chemotherapy---
Combination chemotherapy---
Chromosome--- DNA
46
Chronic- --
Clinica l---
Clinical trial---
·Control group---""

·End Point---

·Experimental Group---""
·Randomized clinical trial---

·Phase I trial---
MTD maximum tolerated dose

3-6
""DLT dose limiting toxicity

·Phase II trial---
14-50

·Phase III trial---
""""""

Creatinine---

Cyst---
Cytokine---

DEXADual Photon X-ray Absorptionmetrystudy--- X

Dexamethasone---

Diagnosis---
Dialysis---
Disease-free survival ---
DLTDose Limiting Toxicity---

DNA---
Drug resistance---
Edema---
Efficacy---
Electrophoresis---

M
Enzyme---
Erythrocytes---

Erythropoietin---

Free Light Chains------Freelite

Gene--- DNA RNA

Gene therapy ---

Genetic--- DNA
Graft-versus-host diseaseGVHD---

Granulocyte---

HematocritHct---
Hematologic---
Hematologist---
Herpes simplex---

""cold sores
Herpes zoster---

""shingles
Hormones---

Humen leukocyte antigen HLA test---

Hypercalcemia---

IgGIgA--- G AG A
G
IgG IgG
""""
""

IgDIgE--- D E
IGM--- M Waldenstrom

Immune system---

Immunodeficiency---
Immunofixation---
M IgGIgA

M
Immunoglobulin Ig---

IgGIgAIgDIgM IgE
Immunosuppression---
""
""
Immunotherapy---""
Incidence----
Induction Therapy---
Informed Consent---

Infusion---
Infusion Pump---
Inhibit---
Injection---
Interferon---

Interleukin---
-2

-6

LDH---
Lesion---
""
Leukocytes---""
Leukopenia---
Lymphocytes ---
Lytic lesions--- X

M proteins M spike---M M

"M " M M
""""
Maintenenace therapy---
Malignenat---
MDRMulti Drug Resistance---
p

Melanoma---

Metastasize---
""

""
MGUSMonoclonal Gammopathy of Undertermined Significance- --
M
Molecule ---

Monoclonal---""

M
Monoclonal antibodies---

Monocyte---
MRIMagnetic Resonance Imaging--- X

MTDMaximum Tolerated Dose---

Myelodysplaseic syndrome---

Myeloid---
""

Myelosuppression---
Neoplasia---
Neoplasm---""""
Neutropenia---

G-CSF Neupogen
Neutrophils---
Oncogene ---

Oncologist---
Osteoblast---
Osteocast---

Osteoid---
Osteonecrosis of the jaws---

Osteoporosis---
X
Palliative treatment---

Patholigical fracture---

Pathology---

PETPositron Emmision Tomographyscan---

Placebo---
Plasma---
Plasma cells---

M

Plasmacytoma---

Plasmapheresis---

Platelet---

Port-Implanted---
/

Prognosis---
Progression-free survival---

Progressive disease---
Protocol---
Precancerous---
Radiation therapy--- X

Radiologist---
X
Recurrence---

Red blood cellsErythrocytes---

Refractory---
Regression---
Relapse---
Remission or Response---
""""

·Complete Remission CR---/

/

·Partial RemissionPR--- SWOG
>50%<70%>50%
RNAribonucleic acid---RNA DNA
RNA DNA
Serum Osteocalcin---

Shingles---"""
Side effects---

Skeletal surveyMetastatic survey---

X /
Stable Disease---<50%
"
" CR PR

Stage---
Stem cells---

Steroid---

Supportive care---

Systemic therapy---
Thrombocytes---"Platelets"
Thrombocytopenia--- 150,000-
250,000 50,000 10,000
TNFTumor Necrosis Factor---

Toxins---
Transfusion---
Transplantation---/

·Bone Marrow transplantation---

·Peripheral blood stem cell transplantation---

·Allogeneic---

·Autologous---
·Matched unrelated donor transplantsMUDs---

·Syngeneic---

Tumor---

Tumor marker---
Vaccine---
""""""

Virus---

Waldensstrom's Macroglobulemia---Waldenstrom
IgM
White blood cells (WBC)---

X-ray---X