Dr. Vij addressed the increased incidence of herpes zoster (shingles) with Velcade in the peri-transplant setting. The dormant herpes zoster virus was reactivated in 43% of the patients in the study. It is important to note that this disturbing side effect of treatment is easily controlled by giving patients Acyclovir or Valtrex prophylaxis for the duration of 4 cycles of Velcade consolidation treatment post transplant.