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'This is the most exciting ASH meeting that I've been to, and I've been a member for over 25 years.'
Morie Gertz, MD
Mayo Clinic

The IMF is pleased to provide you with a broad sampling of myeloma presentations and posters from the 2008 annual meeting of the American Society of Hematology in San Francisco, California. We hope you will find this material informative and useful.

OVERVIEWS OF ASH:
01.04.09     Dr. Rajkumar - ASH 2008 - An Overview of the 50th ASH Annual Meeting and Exposition
December 6-9, 2008
San Francisco, CA
  Dr. Vincent Rajkumar
Mayo Clinic
Rochester, Minnesota
USA
Member, IMF Board of Scientific Advisors
01.04.09     Dr. Anderson - ASH 2008 - An Overview of the 50th ASH Annual Meeting and Exposition
December 6-9, 2008
San Francisco, CA
  Kenneth C. Anderson, MD
Dana-Farber Cancer Institute
Boston, Massachusetts
U.S.A.
Member, IMF Board of Scientific Advisors
01.04.09     Dr. Gertz - ASH 2008 - An Overview of the 50th ASH Annual Meeting and Exposition
December 6-9, 2008 in San Francisco, CA and
  Morie Gertz, MD
Mayo Clinic
Rochester, Minnesota
USA
Member, IMF Board of Scientific Advisors
UPDATE ON BANK ON A CURE RESEARCH:
01.04.09     Dr. Van Ness - ASH 2008 - Analytical Approaches for the BOAC SNP Panel Association with Progression Free Survival in Myeloma
  Brian Van Ness, PhD
University of Minnesota
Institute of Human Genetics
Minneapolis, Minnesota
USA
Member, IMF Board of Scientific Advisors
GENETIC STUDIES:
01.04.09     Dr. Reece - ASH 2008 - The Impact of Cytogenetics on the Outcomes of Treatment with Lenalidomide Plus Dexamethasone in Relapsed or Refractory Multiple Myeloma
  Donna E. Reece, MD
Princess Margaret Hospital
Toronto, Ontario
Canada
Member, IMF Board of Scientific Advisors
01.04.09     Dr. Munshi - ASH 2008 - Alternate Splicing Is a Frequent Event and Impacts Clinical Outcome in Myeloma: A High-Density Exon Array Analysis of Uniformly Treated Newly-Diagnosed Myeloma Patients
  Nikhil Munshi, MD
Dana-Farber Cancer Institute
Boston, Massachusetts
USA
Member, IMF Board of Scientific Advisors
01.04.09     Dr. Morgan - ASH 2008 - Genetic Variation in ADME Genes Is Associated with Thalidomide Related Peripheral Neuropathy in Multiple Myeloma Patients
  Gareth Morgan, MD
Section of Haemato-Oncology
The Institute of Cancer Research
London, United Kingdom
Member, IMF Board of Scientific Advisors
01.04.09     Dr. Morgan - ASH 2008 - High Resolution Genomic Profiling Using Single Nucleotide Polymorphism Microarrays Identifies Multiple Novel Genomic Minimally Deleted Regions in Multiple Myeloma
  Gareth Morgan, MD
Section of Haemato-Oncology
The Institute of Cancer Research
London, United Kingdom
Member, IMF Board of Scientific Advisors
01.04.09     Dr. Goldschmidt - ASH 2008 - Inhibition of Aurora-Kinases for Tailored Risk-Adapted Treatment of Multiple Myeloma
  Hartmut Goldschmidt, MD
Universitätsklinikum Heidelberg und Nationales Centrum für Tumorerkrankungen
Heidelberg, Germany
Member, IMF Board of Scientific Advisors
01.04.09     Dr. Beksac - ASH 2008 - HLA Specificities and Predisposition to the Development of Multiple Myeloma (MM)
  Meral Beksac, MD
Ankara University School of Medicine
Ankara, Turkey
Member, IMF Board of Scientific Advisors
NEWLY-DIAGNOSED: TRANSPLANT ELIGIBLE:
01.04.09     Dr. San Miguel - Updated Follow-up and Results of Subsequent Therapy in the Phase III VISTA Trial: Bortezomib Plus Melphalan–Prednisone Versus Melphalan–Prednisone in Newly Diagnosed Multiple Myeloma
  Jesús San Miguel, MD
Hospital Clinico Universitario
Universidad de Salamanca
Salamanca, Spain
Member, IMF Board of Scientific Advisors
01.04.09     Dr. Knop - ASH 2008 - Bortezomib, Intravenous Cyclophosphamide and Dexamethasone (VelCD) for Previously Untreated Multiple Myeloma: An Interim Analysis of the German DSMM XIa Trial
  Stephan Knop, MD
University Hospital Würzburg
Würzburg, Germany
01.04.09     Dr. Sonneveld - First Analysis of HOVON-65/GMMG-HD4 Randomized Phase III Trial Comparing Bortezomib, Adriamycine, Dexamethasone (PAD) Vs VAD as Induction Treatment Prior to High Dose Melphalan (HDM) in Patients with Newly Diagnosed Multiple Myeloma (MM)
  Pieter Sonneveld, MD, PhD
Erasmus Medical Center
Rotterdam, Netherlands
Member, IMF Board of Scientific Advisors
01.04.09     Dr. Bensinger - ASH 2008 - A Phase II Study of Bortezomib (Velcade®), Cyclophosphamide (Cytoxan®), Thalidomide (Thalomid®) and Dexamethasone as First-Line Therapy for Multiple Myeloma.
  William Bensinger, MD
Fred Hutchinson Cancer Research Center
Seattle, Washington
U.S.A.
Member, IMF Board of Scientific Advisors
01.04.09     Dr. Lokhorst - ASH 2008 - Final Analysis of HOVON-50 Randomized Phase III Study on the Effect of Thalidomide Combined with Adriamycine, Dexamethasone (AD) and High Dose Melphalan (HDM) in Patients with Multiple Myeloma (MM)
  Henk M. Lokhorst, MD
University Medical Center Utrecht
Utrecht, Netherlands
Member, IMF Board of Scientific Advisors
01.04.09     Dr. Kumar - Safety and Efficacy of Novel Combination Therapy with Bortezomib, Dexamethasone, Cyclophosphamide, and Lenalidomide in Newly Diagnosed Multiple Myeloma: Initial Results from the Phase I/II Multi-Center EVOLUTION Study
  Shaji Kumar, MD
Mayo Clinic
Rochester, Minnesota
USA
01.04.09     Dr. Kumar - ASH 2008 - Phase II Trial of Lenalidomide (Revlimid™) with Cyclophosphamide and Dexamethasone (RCd) for Newly Diagnosed Myeloma
  Shaji Kumar, MD
Mayo Clinic
Rochester, Minnesota
U.S.A.
01.04.09     Dr. Kumar - ASH 2008 - Stem Cell Mobilization Following Initial Therapy with Lenalidomide and Dexamethasone in Patients with Newly Diagnosed Multiple Myeloma
  Shaji Kumar, MD
Mayo Clinic
Rochester, Minnesota
U.S.A.
01.04.09     Dr. Palumbo - ASH 2008 - Oral Melphalan, Prednisone, and Lenalidomide for Newly Diagnosed Multiple Myeloma Patients: Kinetics of Neutropenia/Thrombocytopenia and Time to Event Results
  Antonio Palumbo, MD
Divisione di Ematologia dell'Università di Torino
A.O.U. San Giovanni Battista
Torino, Italy
Member,IMF Board of Scientific Advisors
NEWLY-DIAGNOSED: ELDERLY OR NON-TRANSPLANT:
01.04.09     Dr. Palumbo - ASH 2008 - A Prospective, Randomized, Phase III Study of Bortezomib, Melphalan, Prednisone and Thalidomide (VMPT) Versus Bortezomib, Melphalan and Prednisone (VMP) in Elderly Newly Diagnosed Myeloma Patients
  Antonio Palumbo, MD
Divisione di Ematologia dell'Università di Torino
A.O.U. San Giovanni Battista
Torino, Italy
Member,IMF Board of Scientific Advisors
01.04.09     Dr. Palumbo - ASH 2008 - Bortezomib-Doxorubicin-Dexamethasone as Induction Prior to Reduced Intensity Autologous Transplantation Followed by Lenalidomide as Consolidation/Maintenance in Elderly Untreated Myeloma Patients
  Antonio Palumbo, MD
Divisione di Ematologia dell'Università di Torino
A.O.U. San Giovanni Battista
Torino, Italy
Member,IMF Board of Scientific Advisors
01.04.09     Dr. Wijermans - ASH 2008 - Melphalan + Prednisone Versus Melphalan + Prednisone + Thalidomide in Induction Therapy for Multiple Myeloma in Elderly Patients: Final Analysis of the Dutch Cooperative Group HOVON 49 Study
  Pierre Wijermans, MD
Haga Hospital
The Hague, Netherlands
01.04.09     Dr. Hajek - ASH 2008 - The Reduced Intensity Cvd Regimen: A Good Option with Well Balanced Efficacy/Toxicity Ratio for Elderly Patients with Poor Status Performance
  Roman Hajek, MD
University Hospital Brno
Brno, Czech Republic
Member, IMF Board of Scientific Advisors
01.04.09     Dr. Harousseau - ASH 2008 - Superior Outcomes Associated with Complete Response: Analysis of the Phase III VISTA Study of Bortezomib Plus Melphalan–Prednisone Versus Melphalan–Prednisone
  Jean-Luc Harousseau, MD
Hematologie Clinique
CHU Hotel Dieu
Nantes, France
Member, IMF Board of Scientific Advisors
STEM CELL TRANSPLANT:
01.04.09     Dr. Jakubowiak - ASH 2008 - Initial Treatment with Bortezomib (Velcade®), Doxil®, and Dexamethasone (VDD) Is Superior to Thalidomide and Dexamethasone (TD) as Initial Therapy Prior to Autologous Stem Cell Transplantation (ASCT) for Multiple Myeloma (MM)
  Andrzej Jakubowiak, MD
University of Michigan Cancer Center
Ann Arbor, Michigan
U.S.A.
01.04.09     Dr. Lonial - ASH 2008 - A Randomized Phase I Trial of Melphalan + Bortezomib as Conditioning for Autologous Transplant for Myeloma: The Effect of Sequence of Administration
  Sagar Lonial, MD
Winship Cancer Institute
Emory University
Atlanta, Georgia
U.S.A.
Member, IMF Board of Scientific Advisors
01.04.09     Dr. Barlogie - ASH 2008 - Ninety Percent Sustained Complete Response (CR) Rate Projected 4 Years after Onset of CR in Gene Expression Profiling (GEP)-Defined Low-Risk Multiple Myeloma (MM) Treated with Total Therapy 3 (TT3): Basis for GEP-Risk-Adapted TT4 and TT5
  Bart Barlogie, MD, PhD
University of Arkansas for Medical Sciences
Myeloma Institute for Research and Therapy
Little Rock, Arkansas
USA
Member, IMF Board of Scientific Advisors
01.04.09     Dr. Avigan - Fusion Cell Vaccination in Conjunction with Stem Cell Transplantation Is Well Tolerated, Induces Anti-Tumor Immunity and Is Associated with Responses in Patients with Multiple Myeloma
  David Avigan, MD
Beth Israel Deaconess Medical Center
Boston Massachusetts
USA
01.04.09     Dr. Bladé - ASH 2008 - Thalidomide/Dexamethasone (TD) Vs. Bortezomib(Velcade®)/Thalidomide / Dexamethasone (VTD) Vs. VBMCP/VBAD/Velcade® As Induction Regimens Prior Autologous Stem Cell Transplantation (ASCT) in Younger Patients with Multiple Myeloma (MM): First Results of a Prospective Phase III PETHEMA/Gem Trial
  Joan Bladé, MD
Hospital Clinic
Barcelona, Spain
Member, IMF Board of Scientific Advisors
01.04.09     Dr. Niederwieser - ASH 2008 - Overview of the European Bone Marrow Transplant Group (EBMT)
  Dietger W. Niederwieser, MD
University of Leipzig
Leipzig, Germany
01.04.09     Dr. Harousseau - ASH 2008 - Velcade-Dexamethasone versus VAD as Induction Treatment Prior to ASCT in Newly Diagnosed MM. Updated Results of the IFM2005/01 Trial.
  Jean-Luc Harousseau, MD
Hematologie Clinique
CHU Hotel Dieu
Nantes, France
Member, IMF Board of Scientific Advisors
01.04.09     Dr. Cavo - ASH 2008 - Superior Complete Response Rate and Progression-Free Survival after Autologous Transplantation with up-Front Velcade-Thalidomide-Dexamethasone Compared with Thalidomide-Dexamethasone in Newly Diagnosed Multiple Myeloma; Up-Front Response Not Affected by Adverse Prognostic Factors, Including High-Risk Cytogenetic Abnormalities
  Michele Cavo, MD
Bologna University School of Medicine
Seragnoli Institute of Hematology and Medical Oncology
Bologna, Italy
HIGH-RISK MYELOMA:
01.04.09     Dr. Rajkumar - ASH 2008 - Survival in Patients with Newly Diagnosed Myeloma Undergoing Therapy with Lenalidomide and Dexamethasone: Impact of High-Risk Cytogenetic Risk Status on Outcome
  Dr. Vincent Rajkumar
Mayo Clinic
Rochester, Minnesota
USA
01.04.09     Dr. Dispenzieri - ASH 2008 - Primary Therapy with Bortezomib—the Role of Induction, Maintenance, and Re-Induction in Patients with High Risk Myeloma. Update of Results from E2A02
  Angela Dispenzieri, MD
Mayo Clinic
Rochester, Minnesota
USA
01.04.09     Dr. Landau - ASH 2008 - Sequential Administration of Bortezomib, Liposomal Doxorubicin and Dexamethasone (BDD) Followed by Thalidomide and Dexamethasone (TD) Results in Rapid Control of Untreated High-Risk Multiple Myeloma (MM) and Improves Depth of Response
  Heather Landau, MD
Memorial Sloan-Kettering Cancer Center
New York, New York
U.S.A.
RELAPSED-REFRACTORY DISEASE:
01.04.09     Dr. Reece - ASH 2008 - Phase I-II Trial of Oral Cyclophosphamide, Prednisone and Lenalidomide (Revlimid®) (CPR) for the Treatment of Patients with Relapsed and Refractory Multiple Myeloma
  Donna E. Reece, MD
Princess Margaret Hospital
Toronto, Ontario
Canada
Member, IMF Board of Scientific Advisors
01.04.09     Dr. Petrucci - ASH 2008 - Efficacy and Safety of Re-Treatment with Bortezomib (Velcade©) in Patients with Multiple Myeloma: Results from a Prospective International Phase II Trial
  Maria Teresa Petrucci, MD
Università La Sapienza
Rome, Italy
01.04.09     Dr. Reece - ASH 2008 - Treatment of Relapsed and Refractory Multiple Myeloma in Patients with p53 Deletion
  Donna E. Reece, MD
Princess Margaret Hospital
Toronto, Ontario
Canada
Member, IMF Board of Scientific Advisors
01.04.09     Dr. Weber - ASH 2008 - Vorinostat Plus Bortezomib for the Treatment of Relapsed/Refractory Multiple Myeloma: Early Clinical Experience
  Donna Weber, MD
M.D. Anderson Cancer Center
Houston Texas
USA
01.04.09     Dr. Morgan - ASH 2008 - CRD: A Phase 1 Dose Escalation Study to Determine the Maximum Tolerated Dose of Cyclophosphamide in Combination with Lenalidomide and Dexamethasone in Relapsed/Refractory Myeloma
  Gareth Morgan, MD
Section of Haemato-Oncology
The Institute of Cancer Research
London, United Kingdom
Member, IMF Board of Scientific Advisors
NEW AGENTS:
01.04.09     Dr. Jakubowiak - ASH 2008 - Phase I Results of Perifosine (KRX-0401) in Combination with Lenalidomide and Dexamethasone in Patients with Relapsed or Refractory Multiple Myeloma (MM)
  Andrzej Jakubowiak, MD
University of Michigan Cancer Center
Ann Arbor, Michigan
USA
01.04.09     Dr. Kaufman - ASH 2008 - First Trial of Humanized Anti-CD74 Monoclonal Antibody (MAb), Milatuzumab, in Multiple Myeloma
  Jonathan Kaufman, MD
Emory University School of Medicine
Winship Cancer Institute
Atlanta Georgia
USA
01.04.09     Dr. San Miguel - ASH 2008 - Final Results of a Phase II Trial with Plitidepsin (Aplidin) Alone and in Combination with Dexamethasone in Patients with Relapsed/Refractory Multiple Myeloma
  Jesús San Miguel, MD
Hospital Clinico Universitario
Universidad de Salamanca
Salamanca, Spain
Member, IMF Board of Scientific Advisors
01.04.09     Dr. Knop - ASH 2008 - Anti-EGFR Antibody Cetuximab in Refractory or Relapsed Multiple Myeloma: Preliminary Results and Evaluation of Response Prediction in a Phase II Clinical Trial
  Stephan Knop, MD
University Hospital Würzburg
Würzburg, Germany
01.04.09     Dr. Lonial - ASH 2008 - A Phase I MMRC Clinical Trial Testing the Combination of Bortezomib and Tipifarnib in Relapsed/Refractory Multiple Myeloma
  Sagar Lonial, MD
Winship Cancer Institute
Emory University
Atlanta, Georgia
USA
01.04.09     Dr. Miki - ASH 2008 - KRN5500, a Spicamycin Derivative, Exerts Anti-Myeloma Effects through Impairing Both Myeloma Cells and Osteoclasts
  Hirokazu Miki, MD
Tokushima Uiveristy HospitalTokushima, Japan
01.04.09     Dr. Vogl - ASH 2008 - Combined Autophagy and Proteasome Inhibition for Multiple Myeloma: Preliminary Results of a Phase 1/2 Trial of Hydroxychloroquine and Standard Dose Bortezomib for Relapsed or Refractory Myeloma
  Dan T. Vogl, MD
Abramson Cancer Center, University of Pennsylvania School of Medicine
Myeloma Program
Philadelphia, Pennsylvania
USA
01.04.09     Dr. Vij - ASH 2008 - Initial Results of PX-171-004, An Open-Label, Single-Arm, Phase II Study of Carfilzomib (CFZ) in Patients with Relapsed Myeloma (MM)
  Ravi Vij, MD
Washington University School of Medicine
Saint Louis, Missouri
USA
01.04.09     Dr. Lacy - ASH 2008 - Pomalidomide (CC4047) Plus Low-Dose Dexamethasone (Pom/dex) Is Highly Effective Therapy in Relapsed Multiple Myeloma
  Martha Q. Lacy, MD
Mayo Clinic
Rochester, Minnesota
U.S.A.
01.04.09     Dr. Zonder - ASH 2008 - Phase I Study of Elotuzumab (HuLuc63) in Phase I Study of Elotuzumab (HuLuc63) in Relapsed/Refractory Multiple Myeloma
  Jeffrey A. Zonder, MD
Karmanos Cancer Institute
Detroit, Michigan
01.04.09     Dr. Pozzi - ASH 2008 - Promoting Osteoblastogenesis Using a Novel Dkk-1 Neutralizing Antibody in the Treatment of Multiple Myeloma Related Bone Disease
  Samantha Pozzi, MD
Dana-Farber Cancer Institute
Jerome Lipper Multiple Myeloma Disease CenterBoston Massachusetts
USA
2009 IMF Grant Recipient
01.04.09     Dr. Jagannath - ASH 2008 - Initial Results of PX-171-003, An Open-Label, Single-Arm, Phase II Study of Carfilzomib (CFZ) in Patients with Relapsed and Refractory Multiple Myeloma
  Sundar Jagannath, MD
St. Vincent's Comprehensive Cancer Center
New York, New York
USA
Member, IMF Board of Scientific Advisors
01.04.09     Dr. Santo - ASH 2008 - AT7519, a Novel Small Molecule Multi-Cyclin Dependent Kinase Inhibitor, Induces Apoptosis in Multiple Myeloma VIA GSK3β
  Loredana Santo, MD
Dana-Farber Cancer Institute
Boston, Massachusetts
USA
2009 IMF Grant Recipient
RENAL DYSFUNCTION:
01.04.09     Dr. Ludwig - ASH 2008 - Bortezomib-Doxorubicin-Dexamethasone (BDD) for Reversal of Acute Light Chain Induced Renal Failure (ARF) in Multiple Myeloma (MM). Results from a Phase II Study
  Heinz Ludwig, MD
Wilhelminenspital der Stadt Wein
Vienna, Austria
Member, IMF Board of Scientific Advisors
MAINTENANCE THERAPY:
01.04.09     Dr. Morgan - ASH 2008 - Maintenance Thalidomide May Improve Progression Free but Not Overall Survival; Results from the Myeloma IX Maintenance Randomisation
  Gareth Morgan, MD
Section of Haemato-Oncology
The Institute of Cancer Research
London, United Kingdom
Member, IMF Board of Scientific Advisors
ALSO OF INTEREST:
01.20.09     Multiple Myeloma: Finding Your Way Through the Treatment Maze - Selecting the Best Treatment in the Era of Novel Agents
  Audiocast of the IMF Super Friday Program at the 50th ASH Annual Meeting and Exposition

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