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2 Comments

First, I'm interested to know whether the gadolinium that was found to have been retained in tissues -- of human subjects with normal renal function -- was in the chelated form of gadodiamide (Omniscan), or in the ionic GD3+ form.

Second, I'm interested to know whether there has been followup work on this study. One example: Are the effects limited to gadodiamide, or are they seen to some degree with other contrast agents as well.

Note: I'm familiar with Dr. Fujimoto's work, reported here: [http://]www.exp-oncology.com.ua/download/776.pdf. At first blush it may seem inconsistent with the Fulciniti study. But it appears to me that for the cell line and duration used by Fujimoto (RPMI 8226, 24 hours), results were not inconsistent with Fulciniti's in vivo work. For that cell line in Fulciniti's work, myeloma growth was not seen to have been promoted after 24 hours, but it was after 72 hours.

To my understanding, the possibility remains that an unanticipated substantial level of Gd remains in various tissues far longer than 24 hours, and significantly promotes myeloma cell growth.

First, I wonder if it could be confirmed for me that the gadolinium that was found to have been retained in tissues -- of human subjects with normal renal function -- was in the ionic Gd3+ form, not in the chelated form of gadodiamide (Omniscan).

Second, I'm interested to know whether there has been followup work on this study. One example: Are the effects limited to gadodiamide, or are they seen to some degree with other contrast agents as well.

Note: I'm familiar with Dr. Fujimoto's work, reported here: http://www.exp-oncology.com.ua/download/776.pdf. At first blush it may seem inconsistent with the Fulciniti study. But it appears to me that for the cell line and duration used by Fujimoto (RPMI 8226, 24 hours), results were not inconsistent with Fulciniti's in vivo work. For that cell line in Fulciniti's work, myeloma growth was not seen to have been promoted after 24 hours, but it was after 72 hours.

To my understanding, the possibility remains that an unanticipated substantial level of Gd remains in various tissues far longer than 24 hours, and that it significantly promotes myeloma cell growth.

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