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Guide to Myeloma Acronyms and Abbreviations

The following guide identifies commonly used myeloma abbreviations and acronyms.  Another document, The IMF Myeloma Terms and Definitions, defines these terms, and many others, more fully.  A third reference you may also find helpful, The IMF Guide to Drug Names, lists each approved and experimental myeloma drug by its number/letter code, generic name, and brand name.  

Click here to download a PDF version.

06.19.12

Acronym

Meaning

Allo Allogeneic Stem Cell Transplant
Auto Autologous Stem Cell Transplant
ASCT Autologous Stem Cell Transplant

ß2M

Beta 2 Microglobulin

BiRD Biaxin, Revlimid, Dexamethasone
BMT CTN Bone Marrow Transplant Clinical Trials Network
BP Bisphosphonate
CALGB Cancer and Leukemia Group B ( a US cooperative clinical trials group)

CBC

Complete Blood Count

CD34 Cluster of Differentiation 34 (a cell surface protein on hemtopoietic stem cells)
CI Confidence Interval (statistical term)

CR

Complete Remission

Cr Creatinine
CRAB Calcium Renal Anemia Bone Disease

CRP C

C-Reactive Protein

CT Computerized Tomography Scan (3D X-ray)

CyBorD

Cytoxan, Velcade (Bortezomib), Dexamethasone

DCEP

Dexamethasone, Cyclophosphamide, Etoposide and Cisplatin

DEX

Dexamethasone

DPACE

Dexamethasone, Cisplatin, Adriamycin, Cyclophosphamide, Etoposide

DVD

Doxil, Vincristine, Dex

DVT

Deep Vein Thrombosis

EFS

Event Free Survival

EMD Extramedullary Disease (myeloma that grows outside the bone marrow)

FISH

Fluorescent In Situ Hybridization

FLC Free Light Chain
GEP Gene Expression Profile
GIMEMA The Italian myeloma clinical trials group
GMMG The German myeloma clinical trials group

GVHD

Graft Versus Host Disease

HDAC Histone Deacetylase

HDT

High Dose Therapy

HOVON The Dutch clinical trials myeloma group
HR Hazard Ratio (statistical term)
HRSMM High-Risk Smoldering Multiple Myeloma
IEP Immunoelectrophoresis
IFE Immunofixation Electrophoresis
Ig Immunoglobulin
IM Intramuscular (shot or infection into the muscle)

ISS

International Staging System

IV Intravenous (injection into the vein)
KRD Kyprolis (carfilzomib), Revlimid, Dexamethasone
MEL 200 The dose of melphalan administered in ASCT: 200 mg of melphalan per square meter of body mass

MGUS

Monoclonal Gammopathy of Undetermined Significance

MP

Melphalan & Prednisone

MPR Melphalan, Prednisone, Revlimid
MPT Melphalan, Prednisone, Thalidomide
MR Minimal Response (between 25% and 50% response to a drug or regimen in a clinical trial)
MRC Medical Research Council (UK myeloma clinical trials group)
MRD Minimal Residual Disease

MRI

Magnetic Resonance Imaging

mSMART Mayo Stratification of Myeloma and Risk-Adapted Therapy
MTD Maximum Tolerated Dose
NA or N/A Not Available
nCR Near-Complete Response
NDMM Newly Diagnosed Multiple Myeloma
NGF Next-Generation Flow (new 8-color flow cytometry test with software for myeloma)
NGS Next-Generation Sequencing (new DNA-sequencing test)
NR Not Reached

ONJ

Osteonecrosis of the Jaw

ORR Overall Response Rate

OS

Overall survival

PAD Velcade (formerly PS-341), Adriamycin, Dexamethasone
PBSCT Peripheral Blood Stem Cell Transplant
PCLI Plasma Cell Labeling Index
PCR Polymerase Chain Reaction (DNA test, also called ASO PCR or Aleele-Specific Oligonucleotide PCR)

PET

Positron Emission Tomography

PET/CT PET combined with a CT scan
PETHEMA The Spanish myeloma clinical trials group
PFS Progression-Free Survival

PN

Peripheral Neuropathy

PR

Partial Remission

PSCT

Peripheral Stem Cell Transplant

REVLoDEX

Revlimid, Low dose Dexamethasone

RMPT Revlimid, Melphalan, Prednisone, Thalidomide
RRMM Relapsed/Refractory Multiple Myeloma
RQPCR Real-time Quantitative Polymerase Chain Reaction (DNA test)
RVD Revlimid, Velcade, Dexamethasone
sCR Stringent Complete Response (CR plus normal free light chain ratio and no clonal plasma cells)

SCT

Stem Cell Transplant

SD Stable Disease

SMM

Smoldering Multiple Myeloma

SPM Second Primary Malignancy
SQ Subcutaneous (sometimes abbreviated SC)

SRE

Skeletal Related Event

TMI

Too Much Information

TTP

Time to Progression

VAD Vincristine, Adriamycin, Dexamethasone (old standard induction therapy)

VAMP

Vincristine, Adriamycin, Methylprednisolone

VCF Vertebral Compression Fracture
VDT-PACE Velcade, Dexamethasone, Thalidomide, Cisplatin, Adriamycin, Cyclophosphamide, Etoposide

VEGF

Vascular Endothelial Growth Factor

VGPR

Very Good Partial Remission

VRd Velcade, Revlimid, Low Dose Dexamethasone
VTD Velcade, Thalidomide, Dexamethasone
WBLD CT Whole-Body Low-Dose CT
WBLD MRI Whole-Body Low-Dose MRI
ZOL Zoledronic acid (Zometa)

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