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Bone Disease
IMWG Consensus Statement on the Role of Vertebral Augmentation

Understanding Bisphosphonate Therapy
Approximately 80% of all patients with myeloma develop bone disease. Bone disease can cause the bones to become thinner and weaker (osteoporosis), and it can make holes appear in the bone (lytic lesions). In addition to bone disease, myeloma patients may develop a condition called hypercalcemia. Both myeloma bone disease and hypercalcemia can be treated with a group of drugs called bisphosphonates.
IMWG Guidelines for the Use of Bisphosphonates in Myeloma