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REVLIMID®, a potent immunomodulatory derivative (IMiD) of thalidomide, induces apoptosis [programmed cell death] in resistant MM cell lines and patient cells and, more importantly, decreases binding of MM cells to bone marrow stromal cells. The compromise of this relationship between the myeloma cell and its microenvironment results in inhibiting production in the BM milieu of cytokines (IL-6, VEGF, TNF-alpha) mediating growth and survival of MM cells and blocking angiogenesis." (from "Myeloma therapy, from the bench to the clinic," Blood; November, 2002 (vol. 100, no.9, p. 3061)

Clinical Trials
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Randomized Phase III Study Comparing Conventional-Dose Treatment Using a Combination of Lenalidomide (Revlimid®), Bortezomib (Velcade®), and Dexamethasone (RVD) to High-Dose Treatment with Stem Cell Transplant in the Initial Management of Myeloma in Patients up to 65 Years of Age

This study, sponsored by Dr. Paul Richardson of the Dana-Farber Cancer Institute, was designed to answer a very important question in myeloma: In the era of novel drugs, is high-dose therapy (HDT) still necessary in the initial management of multiple myeloma in younger patients? In this study, the addition of HDT to conventional dose treatment (RVD) as compared to conventional-dose treatment (RVD) alone would be considered superior if it significantly prolongs progression-free survival by at least 9 months.

Revlimid Webcasts from American Society of Hematology (ASH) Meeting 2011

Open REVLIMID® (Lenalidomide) Clinical Trials
From the National Cancer Institute's cancertrials.gov, a list of the Revlimid trials that are currently recruiting patients.
Eastern Cooperative Oncology Group Clinical Trial:E1A05
Randomized Phase III Trial of Consolidation Therapy with Bortezomib (Velcade®) & Lenalidomide (Revlimid®) - Dexamethasone (VRD) versus Bortezomib (Velcade®:) - Dexamethasone (VD) for Patients With Multiple Myeloma Who Have Completed a Dexamethasone Based Induction Regimen