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Bone Disease

Since patients may survive for many years post-diagnosis, clinicians have attempted to devise therapeutic approaches in myeloma that would relieve disabling symptoms, in particular severe bone pain, thereby improving quality of life. New therapies are still needed for myeloma bone disease. New targets have been identified and are being addressed in clinical trials.

Bone Disease in Multiple Myeloma
Dr. Brian Durie
Washington, DC 2009 Patient & Family Seminar
August 7-8, 2009
Bone Health in Focus
The significance of bone health in patients with multiple myeloma.

Balloon kyphoplasty is a minimally invasive procedure that uses bone cement to stabilize the fracture, which in turn, reduces bone pain and helps increase the patient’s overall quality of life.
Bone disease and Bisphosphonate Therapy
Approximately 80% of all patients with myeloma develop bone disease. In addition to bone disease, myeloma patients may develop a condition called hypercalcemia. Both myeloma bone disease and hypercalcemia can be treated with a group of drugs called bisphosphonates.

Denosumab is a monoclonal antibody that inhibits RANKL (RANK ligand), a protein that promotes osteoclastic bone destruction.
Understanding Treatment of Myeloma-Induced Vertebral Compression Fractures

As treatment for myeloma improves and patients live longer, it is important to reduce the disability that can result from the painful problem of vertebral compression fractures, which occur when the vertebra collapses or fractures because the bone is too weak to withstand the pressure or stress placed upon it.