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BANK ON A CURE®
02.19.08


GROUNDBREAKING RESEARCH

Bank On A Cure® is the first global myeloma-specific DNA bank and research initiative. Building on the momentum created by the mapping of the human genome, Bank On A Cure scientists are poring over the vast bank of genetic information the IMF has gathered from myeloma patients worldwide to determine the genetic factors common to all of them. By discovering these patterns, we will be able to develop and tailor better treatment options, minimize the adverse side effects of medications, unlock the mysteries of what causes myeloma, and – ultimately – find a cure.

In 2006, Bank On A Cure delivered an extraordinary achievement: from a pool of over a half-million genetic variations that can affect cancer, our researchers targeted 3,400 genes that specifically influence myeloma. From there, they designed the prototype for a myeloma-specific gene-testing chip (called an SNP chip), the very first of its kind.

Now, every genetic sample from our vast DNA bank will run through Bank On A Cure’s specialized DNA testing machines with a copy of this uniquely developed SNP (pronounced “snip”) chip in order to search for patterns and combinations indicative of myeloma. This custom chip is the linchpin of all Bank On A Cure’s data collection and processing. Data analysis using the SNP chip has already produced results:

  • Analyzing patients' drug metabolism and processing.
  • Studying myeloma medication's debilitating side effects, such as deep vein thrombosis and neuropathy.
  • Addressing bone disease.

Bank On A Cure research was recently honored by the American Society of Hematology (ASH) Scientific Committee as part of 2007's "Best of ASH" session.

BANK ON A CURE ® RESEARCH TEAM

Bank On A Cure is an international, collaborative initiative, comprised of world-renowned myeloma researchers. The primary investigators are:

Dr. Hervé Avet-Loiseau
Laboratory of Hematology
University Hospital
Nantes
France
Dr. Dalsu Baris
Staff Scientist
Division of Cancer Epidemiology
National Cancer Institute (NCI)
USA
Cancer Research and Biostatistics (CRAB)
John Crowley, PhD, Director
USA
Dr. Meletios Dimopolous
Professor and Chairman
Department of Clinical Therapeutics
University of Athens School of Medicine
Alexandra Hospital
Greece
Dr. Brian G.M. Durie (SWOG)
National Director for Hematologic Malignancies
Aptium Oncology, Inc.
Specialist in Multiple Myeloma and Related Disorders
Cedars-Sinai Outpatient Cancer Center
USA
Dr. Hartmut Goldschmidt
Professor of Medicine
University of Heidelberg
Germany
Dr. Roman Hajek
Associate Professor
Department of Internal Medicine
University Hospital Brno
Czech Republic
Dr. Gareth Morgan
Professor of Haematology
The Royal Marsden Hospital
United Kingdom
Dr. S. Vincent Rajkumar (ECOG)
Professor of Medicine
Division of Hematology
Mayo Clinic
USA
Dr. Jesús San Miguel
Head, Department of Hematology
Hospital Universitario de Salamanca
Professor of Medicine
Universitario de Salamanca
Spain
Dr. John Shaughnessy
Associate Professor of Medicine
University of Arkansas for Medical Sciences
Director, Lambert Laboratory of Myeloma Genetics
USA
Dr. Pieter Sonneveld
Senior Staff Hematologist
University Hospital Rotterdam
Dijkzlgt Professor of Hematology
Erasmus University, Rotterdam
The Netherlands
Dr. Brian Van Ness
Professor & Department Head
Genetics, Cell Biology and Development
University of Minnesota
USA

BANK ON A CURE ® ADMINISTRATIVE TEAM

The IMF Administrative Team works closely with Bank On A Cure scientists to establish needs, priorities, and timelines:

Michael Katz
Project Manager
David Smith
Project Administrator
Lisa Paik
Project Assistant


 related articles
WHAT IS BANK ON A CURE®?
Overview of Bank On A Cure®
Bank On A Cure® Launch - May 9, 2005


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Background Information
Bank On A Cure is the first comprehensive myeloma-specific cancer patient DNA bank in history. The IMF sponsors this unique program to unlock the DNA door to a cure for myeloma.
WHAT IS BANK ON A CURE®?
A short webcast explaining the groundbreaking IMF research project.

Overview of Bank On A Cure®

Official Launch Materials
Bank On A Cure® Launch - May 9, 2005