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Metabolic-targeting Therapy for Multiple Myeloma
Laurence Catley, MD
Master Medical Research Institute
Queensland, Australia
09.29.10
Despite enormous investment in new therapeutic drugs, multiple myeloma (MM) remains an incurable malignancy. A fundamental problem that limits the success of current MM therapies is that MM cells in the bone marrow (BM) develop a protective survival mechanism. The chemical compound dichloroacetate (DCA) was discovered to induce selective killing of cancer cells by altering their metabolism. We will test whether DCA alters metabolism in MM cells, selectively induces MM cell death and suppresses MM growth in MM-bearing mice. This pre-clinical investigation may offer new opportunities for therapeutic intervention in MM patients.
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