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The Use of Velcade + Melphalan and Prednisone in Elderly Non-Transplant Patients
By Jesús San Miguel, MD

Dr. San Miguel addresses the addition of Velcade to standard MP in elderly patients who are not candidates for SCT. There was an overall response rate of 88%, with a 32% rate of CR by immunofixation. This regimen is equally effective in patients with abnormal cytogenics. Responses occurred rapidly, with a 70% response rate after the first cycle. Fatigue and peripheral neuropathy were the most common side effects.

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