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consolidation & maintenance: are they needed?    back

CONSOLIDATION AND MAINTENANCE
08.03.11
Consolidation is a type of treatment which is administered in a higher dose or more intense fashion over a few days or weeks to achieve further reduction in myeloma tumour burden.  This is used within clinical trials.  This is not a “standard of care” approach to myeloma therapy.

Maintenance is a type of treatment which is administered over a long period of time, typically years, in an effort to sustain or enhance response which has already been achieved with prior therapy.  The therapy can be the same or different than prior therapy.  However, lower dosages are used and adjusted to achieve and sustain long term efficacy and tolerance.

Clinical trials have shown benefits with several types of maintenance including older forms such as with steroids (prednisone or dexamethasone) and α-interferon as well as more recent therapies such as Thalidomide, Revlimid®, and Velcade®.  Currently, many questions remain, including ideal candidates, drug or combinations to use, ideal duration of therapy and risk factors for short term and/or longer term side effects, toxicities or complications.

ASH 2011 presentations that address STEP 7

REFERENCES

©2011 International Myeloma Foundation

 related articles
ASH 2010 Highlights for Patients with Myeloma
The International Myeloma Foundation : Study Says Long-Term Maintenance Treatment Demonstrates 90% Overall Survival Rate


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ASH 2010 Highlights for Patients with Myeloma
Maintenance therapy is discussed on pages 4 and 5.

The International Myeloma Foundation : Study Says Long-Term Maintenance Treatment Demonstrates 90% Overall Survival Rate