• Smoldering myeloma (low risk) - This is very similar to MGUS. The disease levels are higher, but the risk of developing active myeloma is still low.

Table 3 - Smoldering or Indolent Myeloma Diagnostic Criteria: All Three Required 1. Monoclonal protein present in the serum and/or urine 2. Monoclonal plasma cells present in the bone marrow and/or a tissue biopsy 3. Not meeting criteria for MGUS, multiple myeloma, or solitary plasmacytoma of bone or soft tissue * These criteria identify Stage IA myeloma by Durie/Salmon stage.