We are international
Donate
• about myeloma TEXT SIZE   
newly diagnosed?    back

Understanding Serum Free Light Chain Assays
In individuals with myeloma and related disorders such as monoclonal gammopathy of undetermined significance (MGUS), excess light chains enter the bloodstream. as free light chains. The amount of free light chain production is linked to the activity of myeloma or plasma cell growth.
07.11.11
You can view the entire document as a PDF by clicking on the icon below, or by requesting a free hard copy from the Foundation.


Myeloma is a cancer of the plasma cells in the bone marrow. The function of normal plasma cells is to produce antibodies, also known as immunoglobulins, which have an important role in fighting infection. Each type of plasma cell produces only one type of immunoglobulin. Normal immunoglobulins are composed of smaller units called heavy chains and light chains. Each plasma cell also produces only one type of heavy chain and one type of light chain. When the light chains are attached to the heavy chains, the light chains are referred to as bound light chains. When the light chains are not attached to the heavy chains, they are called free light chains. In individuals with myeloma and related disorders such as monoclonal gammopathy of undetermined significance (MGUS), excess light chains enter the bloodstream. as free light chains. The amount of free light chain production is linked to the activity of myeloma or plasma cell growth.


 related articles