Using thalidomide to treat myeloma is a new idea, but thalidomide itself has been studied for many decades. Much has been learned about how thalidomide works in the treatment of different diseases and how its side effects can be treated. Additionally, we now understand how important it is to prevent women who may be pregnant from being exposed to thalidomide.

Thalidomide is currently approved for the treatment of erythema nodosum leprosum, an inflammatory condition seen in some patients with leprosy. However, thalidomide is actively being investigated for the treatment of myeloma. Many patients with myeloma have benefited from this therapy.

This booklet is intended to provide a basic understanding of thalidomide therapy:

• What thalidomide is and how it works to treat myeloma
• How to handle thalidomide safely
• What side effects might be expected while taking thalidomide
• How doctors can minimize side effects
• How thalidomide may be used with other therapies

The information in this booklet may be useful not only to patients, but also to friends, family, loved ones, and other caregivers. Please remember that myeloma, like all cancers, is a complicated disease. Specific questions about treatment should be addressed by a doctor or nurse.