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July 16, 2002 IMF Myeloma Minute
What's New in Myeloma Research:

The following abstracts have appeared in the medical journal Leukemia. Should you receive an error message indicating that your session has expired, please use the link market "guest access" -- this will allow you to view each article abstract.

The cholesterol lowering drug lovastatin induces cell death in myeloma plasma cells.

Distinct IL-6 signal transduction leads to growth arrest and death in B cells or growth promotion and cell survival in myeloma cells.

A novel mutation involving the carboxy terminal region of the FGFR3 gene in a multiple myeloma patient with t(4;14).

Analysis of IL-6-mediated growth control of myeloma cells using a gp130 chimeric receptor approach.

IL-1 expression in IgM monoclonal gammopathy and its relationship to multiple myeloma.

Frequent inactivation of the cyclin-dependent kinase inhibitor p18 by homozygous deletion in multiple myeloma cell lines: ectopic p18 expression inhibits growth and induces apoptosis.

Items of Interest:

IMF Scientific Advisor, Dr. Robert Kyle to be Interviewed on National Public Radio
Tune in to your local NPR radio station on Thursday, July 18 from 11:00 a.m. to noon E.S.T. to hear an interview with myeloma patient, Dr. Michael Gearin-Tosh, author of the book "Living Proof" and Dr. Robert Kyle. The doctors will be interviewed on the show "The Connection". Click here for a listing of radio stations that carry NPR throughout the United States. A review of "Living Proof", written by Dr. Brian G.M. Durie can be found on page four of the February 2002 issue of Myeloma Today.

As featured in this month's issue of CURE Magazine:

Deep in the Bone: Managing Multiple Myeloma
?It?s smart,? Lee Grayson says ruefully, describing the myeloma he?s been fighting for eight years. ?It?s an immune system cell, and it?s wonderfully designed to help protect your body. So now you have this cell that?s turning on you, but because it?s so wonderfully designed it?s hard to get rid of the darned thing." Click here to read this in-depth article about multiple myeloma. The article appears in the current issue of CURE, a new magazine for cancer patients and their caregivers. For a free subscription to CURE, click here.

Important Dates to Remember:

CancerCare Peripheral Neuropathy Teleconference
Tuesday, July 30, 2002
1:00 p.m. - 2:00 p.m. ET
This teleconference is free, but participants must register online or by calling (800) 813-HOPE.

IMF Patient & Family Seminar: Chicago, IL
August 16th and 17th

International Myeloma Foundation Multiple Myeloma Awareness Week
August 26th - September 1st

Ribbon of Hope: Making A World of Difference 12th Anniversary Gala
Washington D.C.
October 5th

IMF Patient & Family Seminar: Seattle, WA
November 8th and 9th

IMF Patient & Family Seminar: Los Angeles, CA
January 24-25, 2003

Clinical Trials:

Melphalan, Total-Body Irradiation, and Peripheral Stem Cell Transplantation Compared With Combination Chemotherapy in Treating Patients With Previously Untreated Multiple Myeloma.

Combination Chemotherapy With or Without Interferon alfa in Treating Patients With Previously Untreated Multiple Myeloma.

Combination Chemotherapy in Treating Patients With Multiple Myeloma.

Conditioning Therapy and Blood or Marrow Transplantation in Patients With Severe Hematologic Malignancy.

Epoetin Alfa in Patients With Multiple Myeloma and Chemotherapy Related Anemia.

Three Regimens For the Prevention of Delayed Nausea After Chemotherapy in Patients With Chemotherapy-Naive Cancer.

Exciting Opportunities:

Multiple Myeloma Quilt of Courage
There's still time to order a square for the IMF's Multiple Myeloma Quilt of Courage. The Multiple Myeloma Quilt of Courage is a creative project designed to celebrate the lives of those affected by multiple myeloma. For a minimum donation of $25, you will receive a 12x12 inch cotton fabric square to decorate in any manner that you choose (sewing, iron-on design, fabric paint, etc.).

Order the IMF's Unique Holiday Greeting Cards Early and Save $10!
Last year, the IMF debuted its first-ever holiday greeting cards, designed by our talented, young IMFers. We are pleased to offer two different sets of cards - a Christmas Set and a Holiday Set. Cards are sold in sets of ten (with envelopes) and each set contains two different images. The back of each card highlights the artist and offers information about myeloma and the IMF. Proceeds from the sale of the cards will support the many patient services offered by the IMF. These cards are a wonderful way to help raise awareness of multiple myeloma while sending some holiday cheer at the same time! The cards usually sell for $20 per set. However, if you order early, you can get these very special cards for only $10 per set. Cards can be ordered online, or by calling the IMF at (800) 452-CURE.

Help Us Help Others...
As a non-profit organization, the IMF is completely dependent on the support of our members. Please consider showing your support by making a tax-deductible donation today. Donations in honor of a friend or family member make great gifts and are a wonderful way to celebrate a special occasion. You can donate online or by calling the IMF at (800) 452-CURE. We sincerely thank you for your support.

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