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January 10, 2002: IMF Myeloma Minute

Research Updates:

How myeloma lyses bone
Blood, 15 December 2001

Myeloma cells induce imbalance in the osteoprotegerin/osteoprotegerin ligand system in the human bone marrow environment.
Blood, 15 December 2001

Cyclosporin A combined with vincristine, doxorubicin and dexamethasone (VAD) compared with VAD alone in patients with advanced refractory multiple myeloma: an EORTC–HOVON randomized phase III study.
British Journal of Haematology

Thalidomide in refractory and relapsing multiple myeloma.
Semin Oncol 2001 Dec.

Stem Cell Transplant Patients Die Sooner if Depressed
(Courtesy of Acurian.com)

Mayo Clinic Study Shows Thalidomide Significantly Affects Early-stage Multiple Myeloma
(Courtesy of Acurian.com)

Clinical Trials:

Phase I Study of 2-Methoxyestradiol in Patients With Advanced Solid Tumors

Phase II Study of Autologous Peripheral Blood Stem Cell (PBSC) Transplantation Followed By Non-Myeloablative PBSC Transplantation in Patients With Multiple Myeloma

Phase III Randomized Study of Doxorubicin, Dexamethasone, and High-Dose Melphalan With or Without Thalidomide in Patients With Multiple Myeloma

These clinical trials were added to the NCI's database in January 2002. For a comprehensive listing of ongoing clinical trials available to myeloma patients, please visit the IMF's clinical trials page. Interested in learning more about clinical trials? Visit the NCI's Understanding Trials page for informative answers to common questions about clinical trials.

IMF News:

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