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Darzalex® (also known by its generic drug name, daratumumab) is a monoclonal antibody that enlists immune system cells to help attack and kill myeloma cells. It is a highly effective medication to treat myeloma. Although antibodies are a naturally-occurring part of the immune system, Darzalex and other antibodies used to treat cancer are made in a laboratory. A laboratory-made antibody is designed to function like a naturally occurring antibody (or “immunoglobulin,” as an antibody is also known) and to target a specific single protein on the surface of cancer cells. It is therefore also called a “targeted therapy.” This booklet will familiarize you with the way Darzalex works, how it was tested and approved, how and when it is administered, its possible side effects, and how to manage those side effects.