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Jerry Petet
07.01.98

jlpetet@hotmail.com

1950 / Class of '95 / Type: IgG Kappa / Last Update: 7/98 - solitary extramedullary plasmacytoma followed by extensive bone involvement

I am receiving 90 mg of Aredia once a week. My oncdoc believes this is the best course for me at this time. Its due in part to my high amount of bone involvement and he is also concerned with the side effects of Dexamethasone on my bone marrow. He wants to give my bones the best shot possible at lasting longer. I have been on the once a week now for four weeks, before that he had me on it every three weeks like most others I have heard about. Right now I am at the end of my first of three Dexamethasone cycles prior to a stem cell collection.

Now I would like to give you some background on me and my beast. I'm a 47 year old male who has a wife, five daughters (only one left at home) and a son, and six grandkids. I was diagnosed in Jan. 95 with IgG Kappa Multiple Myeloma with at that time a solitary extramedullary plasmacytoma involving T5. I was given Melphalan and Prednisone, along with local radiation to T5..

In March of 96 it become active again and since it didn't respond well to the Melphalan/Prednisone, I was given combination chemotherapy of Vincristine, cyclophosphamide, doxorubicin, and Prednisone. The disease made itself known again in Dec of 97 via a compression fracture at L1 and rib pain. My lower back was treated with radiation and then the oncdoc in PA put me on BCNU. My company then transferred me down here to GA., God is watching over me, and I found a real good oncdoc. The first thing he did was run some new tests, and took more X-Rays. My IgG was still at 3550 after three cycles of BCNU and the x-rays showed a lot of bone involvement, lytic lesions from my skull down to my toes. My oncdoc then sent me out to Arkansas for a second opinion and an evaluation. The ACRC found that my IgG was still 2511, serum M protein 1.1, IgA 139, IgM 35, C-reactive protein 0.81, My X-rays and MRI show nonexpansile lytic lesions involving my skull, left lower ribs, lumbar spine, shoulders, hands and lower extremities, the MRI shows diploid, nonexpansile lesions and bone marrow signal intensity of the spine and the pelvis is isointense and heterogenous with multiple focal lesions to all the spine and pelvis. None of which is expansile. My preliminary cytogenetics on

the bone marrow show four cells which are normal 46xy and one cell which is 46xy -4 and -13. The deletion 13 is considered a high-risk abnormality. Therefore my oncdoc, who is great, and me have decided at least for now that a BMT or a PBSCT are not my first line of defense against the beast. One thing ACRC and my oncdoc agree on is that BCNU was not the treatment that I need at this time. We are going ahead with the stem cell collection so I'll have something in reserve for the beast. I'm sorry this is so long and probably confusing, I know it is to me but thanks to my oncdoc and this list I understand a lot more than what I did a few short weeks ago.

I am receiving 90 mg of Aredia once a week. My oncdoc believes this is the best course for me at this time. Its due in part to my high amount of bone involvement and he is also concerned with the side effects of Dexamethasone on my bone marrow. He wants to give my bones the best shot possible at lasting longer. I have been on the once a week now for four weeks, before that he had me on it every three weeks like most others I have heard about. Right now I am at the end of my first of three Dexamethasone cycles prior to a stem cell collection.

You are all in my prayers. My God Guide Us and The Doctors who Care for Us amen.


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