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Identification of Gene Networks Regulated by Glucocorticoids in Myeloma
Nancy Krett,PhD
Robert H. Lurie Comprehensive Cancer Center
Northwestern University
Chicago, Illinois, USA

Funded by the Trooper Benson Research Fund/Carol & Benson Klein

Glucocorticoids (GC) are an important part of myeloma therapy; however this therapy stops working with the development of resistance decreasing the effectiveness of this drug. A functional glucocorticoid receptor is frequently missing in GC-resistance; therefore the ability to stimulate the GC-response network in myeloma cells in the absence of receptor may provide a new therapeutic approach. My studies will develop an understanding of the primary targets of the GC signaling network which induce cell death and not the unwanted side effects to provide a means for developing new therapeutic targets which could be effective when traditional GC-based therapies fail.

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