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What is an M spike and is it different from the M Protein?
Myeloma cells characteristically produce and release into either the blood or urine monoclonal proteins. Monoclonal proteins are referred to as either, M-protein, para protein or M spike. They are terms that mean the same thing.

The monoclonal protein is an immunoglobulin and in myeloma cells one or more mutations have occurred in the genes responsible for immunoglobulin production. Typically, the antibody function of the immunoglobulin is lost and since it is not performing its antibody function normally, more and more are produced therefore causing an increase in protein levels. (For more information please refer to Multiple Myeloma Concise Review Of The Disease And Treatment Options)

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