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Common Symptoms Of Multiple Myeloma
11.21.09

TABLE 2: MEDICAL PROBLEMS RELATED TO MYELOMA

Effects Of Increased
Myeloma Cells In Bone
Marrow

Cause

Impact On Patient (Symptoms)

Anemia

Decrease in number and activity
of red blood cell-producing
cells.

  • Fatigue
  • Weakness

High protein level
(in blood and/or urine)

Abnormal or monoclonal protein produced by the myeloma cells is released into the bloodstream and can pass into the urine (where it is called Bence Jones protein)

  • Sluggish
    circulation
  • Possible kidney
    damage

Bone Damage:
• Thinning (osteoporosis) or
• Areas of more severe
damage cause lytic lesions, fracture or collapse of a vertebra

The myeloma cells activate osteoclast cells, which destroy bone, and block osteoblast cells, which normally repair damaged bone.

  • Bone pain
  • Bone swelling
  • Fracture or collapse
    of a bone

High blood calcium

Release of calcium from damaged
bone into bloodstream

  • Mental confusion
  • Dehydration
  • Constipation
  • Fatigue
  • Weakness

Reduced normal immune system function against infection

The myeloma cells block production of normal antibodies against infection

  • Susceptibility to
    infection
  • Delayed recovery
    from infection

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