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Myeloma Minute
March 28, 2008
Welcome to the IMF's Myeloma Minute
News about myeloma treatment, research, support and the myeloma community
from the International Myeloma Foundation.


The IMF would like to welcome Loraine Boyle as the newest member of the foundation's Board of Directors
Loraine became involved with the IMF after losing her husband, the actor Peter Boyle, to myeloma. She is a writer and editor, and is active in community organizations and fundraising for her alma mater, Brown University.

NEW! The Myeloma Manager™ Personal Care Assistant™

Another exciting first from the IMF!
Free software to help manage and understand your lab results, and more!

EMEA Recommends New Contraindication For Velcade (bortezomib), EuropeThe European Medicines Agency (EMEA) has recommended that VELCADE (bortezomib) should not be used in multiple myeloma patients who are diagnosed with either acute diffuse infiltrative pulmonary disease or pericardial disease.

The EMEA’s Committee for Medicinal Products for Human Use (CHMP) concluded during its March 2008 meeting that the benefits of VELCADE are greater than its risks, except in patients with acute diffuse infiltrative pulmonary and pericardial disease. The CHMP therefore recommended contraindicating the use of VELCADE for these patients.

European Summary of Product Characteristics (SmPC) has been updated to reflect these two new contraindications. This change is limited to the European label only. The United States Package Insert is not affected and does not contain a contraindication for acute infiltrative lung disease or pericardial disease. The only contraindication in the U.S. label is for those patients with hypersensitivity to bortezomib, boron or mannitol.

Expressive Writing May Aid Cancer Patients
Researchers have found that a single, 20-minute writing session helped change the way some cancer patients thought or felt about their disease. That, in turn, seemed to improve how they rated their quality of life.
(from Reuters by way of Medline)

Mayo Clinic cancer model to speed up drug research
After a six-year effort, Mayo researchers in Scottsdale proved that a gene called MYC is instrumental in converting a benign tumor called MGUS into one that eventually becomes myeloma. (from the Arizona Republic)

New Biological Agents Added to Treatment Algorithm for Multiple Myeloma
Novel therapy using several targeted agents has been incorporated into new guidelines from the National Comprehensive Cancer Network (NCCN) for treatment of multiple myeloma (from Doctor's Guide)

Caring for Your Bones When You Have Multiple Myeloma
New from CancerCare's free Telephone Education Workshops
April 2, 2008 from 1:30 p.m. - 2:30 p.m. ET

Orphan drug designation granted for monoclonal antibody, BT-062
While chemotherapy attacks healthy tissue as well, BT-062 attaches itself selectively to a protein found in high densities in malignant cells. (from Ad-Hoc-News.de)

Immunomedics' Milatuzumab Receives FDA Orphan Drug Designation for Therapy of Multiple Myeloma
The company has initiated Phase I/II studies to evaluate the therapeutic potential of milatuzumab in patients with multiple myeloma (from PrimeNewswire)

Array BioPharma Advances p38 / Tie2 Inhibitor, ARRY-614, into Phase 1 Clinical Trial
Researchers believe the dual inhibition of p38 and Tie2 may produce additive and/or synergistic effects with other therapies in treating multiple myeloma. (from TradingMarkets.com)

Oncolytics Biotech Inc. Collaborators to Present Reovirus Research at AACR Annual Meeting
"Targeting Multiple Myeloma with Oncolytic Viral Therapy" covers preclinical work using reovirus as a purging agent during autologous stem cell transplants for multiple myeloma. (from CNW Telbac)

Publication of Clinical Results Underscores VELCADE(R) (Bortezomib) For Injection Based Therapy As a Standard of Care In Newly Diagnosed Multiple Myeloma Patients
Trial results of combination therapy VELCADE, melphalan and prednisone (VcMP) reported a 32 percent complete remission rate with 85 percent of patients alive at three years.(from PR News)

SpringAH, SPRING! Time to start planning your FUNdraisers!
From a day of beauty to a walk in the clouds, from yard sales to concerts, IMFers are creating fun days to raise money to help support the important work that the IMF is doing in both research and education. Here are some suggestions for your next event!

(IMF Scientific Advisors are marked with an *)


  • DOXIL® trials

    Phase I/II trial of combination CCI-779 (temsirolimus) and bortezomib (Velcade) in relapsed and/or refractory multiple myeloma. Principal investigator: Irene Ghobrial, MD, Dana-Farber Cancer Institute, Boston, MA., 617-632-4198.

    Phase I trial of lenalidomide and CCI-779 in patients with relapsed or refractory multiple myeloma. Principal investigator: Craig Hofmeister, MD, Ohio State University Medical Center, Arthur G. James Cancer Hospital, 614-293-4976.

If you would like more information about any clinical trial, you can call the IMF Hotline at 800-452-CURE. The Myeloma Matrix has a current list of all myeloma trials from pre-clinical to recently FDA approved. If you would like to browse trials currently open for enrollment, visit the Clinical Trials page of the IMF web site. Among the links, you will find EmergingMed, with whom the IMF has entered into a partnership to assist you in matching trials to your particular patient profile (i.e., stage of disease, previous treatment, how well you are able to carry out the activities of daily living, etc.) and by doing so, increase your chances of being eligible. You can also learn more about clinical trials by reviewing materials from the National Cancer Institute.

Note: Some of the international seminar cities have been set, but the venues and agendas are still in the works. Check back often if you are interested in attending, as we post the sites and speakers as they are confirmed.

2nd Annual Living with Myeloma Conference - Scottsdale, Arizona
March 29, 2008
Vienna Patient & Family Seminar - Vienna Austria
April 25-26, 2008
Barcelona Doctors Regional Community Workshop - Barcelona, Spain
May 28, 2008
Valencia Patient & Family Seminar - Valencia, Spain
May 31, 2008
Ulm Regional Community Workshop - Ulm, Germany
June 25, 2008
Stuttgart Regional Community Workshop - Stuttgart, Germany
June 26, 2008
Seattle Patient & Family Seminar - Seattle, Washington
June 27-28, 2008
Boston Patient & Family Seminar - Boston, Massachusetts
July 25-26, 2008
Short Hills Patient & Family Seminar - Short Hills, New Jersey
August 8-9, 2008
San Diego Patient & Family Seminar - San Diego, California
August 22-23, 2008
5th International Symposium on Clinical Applications of Serum Free Light Chain Analysis - Bath, United Kingdom
September 18-19, 200

The IMF's comprehensive "How-to-FUNdraise" guide is what you need if you're thinking about fundraising in your community but don't know where to start. The guide contains the A - Z of fundraising ideas--like running in a local marathon and asking for donations per mile for myeloma; having a holiday party, where you charge a cover and hold a raffle; asking your local supermarket to donate wine and cheese, then selling tickets and having a cocktail party--as well as tips and guidelines for success. Check out the FUNdraisers below and show your support by donating to their effort online:

Third Annual Music Against Myeloma - New York, New York
April 24, 2008
9th Annual "JC" Golf Tournament - St. Cloud, Minnesota
May 17, 2008
IMF Charity Golf Outing - Yorkville, Illinois
July 12, 2008
Cents for Cells
Beth Morgan is helping the IMF by raising a penny for each stem cell that will be collected for her BMT. She has dedicated Cents for Cells to the memory of Chris Hollyer.
Commissions for Chris: A Campaign to Honor Chris Hollyer
Jo Marie Gray is donating her new-client commissions from the sale of Arbonne Cosmetics to the Chris Hollyer Research Fund at the IMF.
Clyde's Ride for the Cure
Clyde is riding his bicycle to support the work of the IMF. "I say, 'until there is a cure I ride for the IMF.'"
Debbie Exner's Walk for Myeloma
Debbie walked the PF Chang Half Marathon in Phoenix on January 13, 2008 to raise money for the IMF in honor of her mother. You can still donate to her cause.
Losing Weight to Gain Awareness
Debi is losing weight to raise money for research and the awareness programs of the IMF.
Miles for Myeloma
Larry Bartolin is a six-year survivor of multiple myeloma, and is riding his motorcycle to raise funds and public awareness.
Spirit of 76
James Conrad is 76. On New Year's Day, he started his 'Run for a Cure' with an objective of 760 miles and donations/pledges of $7600.

As a non-profit organization, the IMF is completely dependent on the support of our members. Tax-deductible donations in honor of a friend or family member make great gifts and are a wonderful way to celebrate a special occasion. You can donate online or by calling the IMF at (800) 452-CURE. And you can order beautiful tribute cards to send out to your friends and family every time you make a donation in their honor to the IMF.We sincerely thank you for your support.
Shop for the IMF
Shop with the leading merchants on the Internet, receive the same price as anyone else visiting their sites, and support the IMF at the same time!
How About Hong Kong?
Or Cancun or Sydney. No matter where you want to go, IMF Travel Advantage has a package for you.

Read the latest issue of the IMF Travel Advantage newsletter for these and other fabulous trips. Great prices and you are helping the IMF with every vacation.
Caregiver Daily Journal

Caregiver Daily Journal
If you know a caregiver, the IMF's own Sylvia Baca has written a journal to help document the daily care they give their loved one. It's $25, with all profits going to support the programs of the IMF..

Sarah Klein's Bracelets

Sterling Bracelets by Sarah Klein
Sarah Klein's father, Benson, was diagnosed with myeloma in 1998, and has been in remission for 8 years.
Sarah wants to give back to the IMF in her own creative way and has designed two special bracelets made up of semi-precious healing stones. A portion of the proceeds from the sale of these bracelets is being donated to the IMF.

Multiple Colors for Multiple Myeloma Keychains and Earrings
Bring rainbows of happiness, color and light into your loved ones' lives with an IMF keychain or Swarovski crystal earrings.

Arbonne Cosmetics
Jo Marie Gray is donating her new-client commissions from the sale of Arbonne Cosmetics to the Chris Hollyer Research Fund at the IMF.
IMF Logo Items
Let the world know that you support the groundbreaking research and innovative patient support programs of the IMF with a hat or shirt or bracelets!
See more exciting ways to help the IMF continue its important work in education, support and research.


National Cancer Institute Announces Availability of New Easy to Read Radiation Therapy Educational Resources

Written for patients and health care providers, this new radiation therapy series includes:

Designed in easy-to-read and understand formats, these resources provide straightforward information to help patients understand how radiation therapy works and how to best manage its side effects. The patient-centered publications encourage individuals to fully participate in their care by providing personalized tips and key questions to foster discussion between patients and providers.

Help for Underinsured Myeloma Patients
Thanks to the advocacy of the IMF, the Chronic Disease Fund has received an infusion of money to help them meet the needs of underinsured patients with multiple myeloma. The fund is designed to help patients with their insurance co-payments and/or their Medicare Part D 'doughnut holes.' Patients must qualify based on financial need. To speak with a representative of the Chronic Disease Fund, please call 877-968-7233, or contact them through their web site at cdfund.org.

Mensajero del Mieloma
La IMF quiere enviar información sobre el mieloma en español a todos los pacientes, familiares e interesados. Para suscribirse al correo electró nico (enviaremos cuatro ejemplares al año), por favor, env íe su dirección a mensajero@myeloma.org. ¡Gracias!


International Staging System

A tool to help understand the current status of the disease and the questions you should be asking.

Check out HealthTalk's Multiple Myeloma Education Network and Andrew Schorr's Patient Power.

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Official Newsletter of the IMF!

Many thanks to the supporters of The Myeloma Minute:
Celgene Corporation and The Binding Site.
Please call the hotline (800) 452-CURE (800-452-2873) or email TheIMF@myeloma.org if you have any questions.
Copyright 2008. International Myeloma Foundation. All Rights Reserved.

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