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Myeloma Minute - November 21, 2007
11.21.07
Welcome to the IMF's Myeloma Minute
News about myeloma treatment, research, support and the myeloma community
from the International Myeloma Foundation.

WHAT'S NEWS



HAPPY THANKSGIVING TO YOU AND YOURS FROM THE IMF!

Two New Trials Have Opened That You Will Want to Know About

  • CC4047

    The IMIDs are a class of drugs that have been important for myeloma. They include Thalomid (thalidomide) and Revlimid. A Phase II trial has opened at Mayo Cinic (MN, AZ and FL) for CC4047. CC4047 is a new IMID under development. Patients with relapsed disease with 3 or fewer previous treatment regimens are eligible.

    Phase II trials build on Phase I trials. Phase I trials are the first tests of new drugs with human subjects and aim to establish that the drug is safe and identify a safe, tolerable dose. Phase II trials like this one aim to determine if the drug is effective against the disease when given at the identified dose.

    Anyone interested in finding out more about this trial and/or how to participate should contact Dr. Martha Lacy or her study assistant, Melanie Thompson, at 507-266-0733. Please note that this trial is only available via the three Mayo facilities in Minnesota, Florida and Arizona and there are a limited number of slots available (30) for this trial. If this trial shows positive results, a much larger randomized Phase III trial would then be undertaken and this trial would be more broadly accessible.

  • The Eastern Cooperative Oncology Group's E1A05 (The trial description has been corrected.)

    This is a randomized study using Bortezomib (also called Velcade) in combination with a steroid, dexamethasone (also called Decadron), with and without Lenolidamide (also called Revlimid.) Patients are elegible to participate if they have completed a dexamethasone-based treatment as their first treatment for myeloma and are not going on to a stem cell transplant at this time.

    Patients will be randomly assigned to one of two groups:

    * Group 1 will receive Bortezomib with dexamethasone

    * Group 2 will receive Lenalidomide with dexamethasone and Bortezomib

    All patients will participate in a Quality of Life Survey during treatment and after treatment. All patients will be followed for up to seven years to assess the long-term effects of the study treatements.


Stress Hormone May Hasten The Progression Of Certain Blood Cancers
Researchers focused on three multiple myeloma tumor cell lines, each representing a different stage in the life of the disease, for their experiments. While all three tumor cell lines reacted to the presence of norepinephrine, only one, a cell line known as FLAM-76, responded strongly to the hormone. (from EurekAlert)


ADVOCACY NEWS
by Christine Murphy

On November 13th, the President vetoed the fiscal year (FY) 2008 Labor, Health and Human Services (LHHS) Appropriations bill.  The FY 2008 LHHS Appropriations bill included a $30 billion ($1.1 billion or 3.8% increase over 2007) for the National Institutes of Health (NIH).  The National Cancer Institute (NCI) received $4.9 billion, an increase of $128 million.  The President’s FY 2008 budget proposed a $278 million cut below the FY 2007 level for the NIH.

The President's veto of the FY 2008 LHHS Appropriations bill was sustained in the House of Representatives on October 15th by a vote of 277-141. A total of 288 votes were needed to override the veto (2/3 of the current membership in the House) It is unclear what the next steps will be for the FY 2008 LHHS Appropriations bill.

Currently, Congress is working with the White House on a deal to cut all spending in the appropriations bills by $11 billion.  House LHHS Appropriations Subcommittee Chairman David Obey (D-Michigan) stated that future LHHS deals could eliminate all Congressional earmarks in an effort to move closer to the President’s proposed budget.  Based on past history, the FY 2008 LHHS Appropriations bill could be included as part of a larger omnibus appropriations bill in mid-December.


WHAT'S NEW IN RESEARCH
ARTICLES
(IMF Scientific Advisors are marked with an *)
CLINICAL TRIALS
If you would like more information about any clinical trial, you can call the IMF Hotline at 800-452-CURE. The Myeloma Matrix has a current list of all myeloma trials from pre-clinical to recently FDA approved. If you would like to browse trials currently open for enrollment, visit the Clinical Trials page of the IMF web site. Among the links, you will find EmergingMed, with whom the IMF has entered into a partnership to assist you in matching trials to your particular patient profile (i.e., stage of disease, previous treatment, how well you are able to carry out the activities of daily living, etc.) and by doing so, increase your chances of being eligible. You can also learn more about clinical trials by reviewing materials from the National Cancer Institute.

UPCOMING SEMINARS AND CLINICAL CONFERENCES
Little Rock Regional Community Workshop - Little Rock, Arkansas
December 1, 2007
Planning for Treatment With or Without Transplant: Balancing Efficacy, Toxicity, and Quality of Life for the Patient with Multiple Myeloma
Save the Date! Friday Satellite Symposium on December 7, 2007 preceding the 49th ASH Annual Meeting
.
St. Louis Regional Community Workshop - St. Louis, Missouri
December 15, 2007
Atlanta (Buckhead) Patient & Family Seminar - Atlanta, Georgia
February 15-16, 2008
Seattle Patient & Family Seminar - Seattle, Washington
June 27-28, 2008
San Diego Patient & Family Seminar - San Diego, California
August 22-23, 2008

UPCOMING EVENTS
The IMF's comprehensive "How-to-FUNdraise" guide is what you need if you're thinking about fundraising in your community but don't know where to start. The guide contains the A - Z of fundraising ideas--like running in a local marathon and asking for donations per mile for myeloma; having a holiday party, where you charge a cover and hold a raffle; asking your local supermarket to donate wine and cheese, then selling tickets and having a cocktail party--as well as tips and guidelines for success. Check out the FUNdraisers below and show your support by donating to their effort online:

Multiple Myeloma Night with the Philadelphia Phantoms - Philadelphia, Pennsylvania
December 14, 2007

An Evening of Believing - Lewisville, Texas
February 23, 2008
Commissions for Chris: A Campaign to Honor Chris Hollyer
Jo Marie Gray is donating her new-client commissions from the sale of Arbonne Cosmetics to the Chris Hollyer Research Fund at the IMF.
Cents for Cells
Beth Morgan is helping the IMF by raising a penny for each stem cell that will be collected for her BMT. She has dedicated Cents for Cells to the memory of Chris Hollyer.
Clyde's Ride for the Cure
Clyde is riding his bicycle to support the work of the IMF. "I say, 'until there is a cure I ride for the IMF.'"
Miles for Myeloma
Larry Bartolin is a six-year survivor of multiple myeloma, and is riding his motorcycle to raise funds and public awareness.
Losing Weight to Gain Awareness
Debi is losing weight to raise money for research and the awareness programs of the IMF.

VISIT THE IMF HOLIDAY BOUTIQUE
Time to start thinking about the coming holidays. Shopping in the IMF Holiday Boutique is the perfect opportunity to help your gifts give twice - once to the recipient, and once to the myeloma community through the IMF.
As a non-profit organization, the IMF is completely dependent on the support of our members. Tax-deductible donations in honor of a friend or family member make great gifts and are a wonderful way to celebrate a special occasion. You can donate online or by calling the IMF at (800) 452-CURE. And you can order beautiful tribute cards to send out to your friends and family every time you make a donation in their honor to the IMF.We sincerely thank you for your support.
Shop for the IMF
Shop with the leading merchants on the Internet, receive the same price as anyone else visiting their sites, and support the IMF at the same time!
Imperial Jewels of China, 2008
Cruise the mighty Yangtze river, and marvel at the mystical scenery of Asia's most revered and dramatic natural attractions.
Read the latest issue of the IMF Travel Advantage newsletter for this and other fabulous trips. Great prices and you are helping the IMF with every vacation.
Difford Bracelets Multiple Myeloma Awareness Bracelets
Beautiful custom made jewelry to honor those who have joined the struggle against multiple myeloma.

Caregiver Daily Journal

Caregiver Daily Journal
If you know a caregiver, the IMF's own Sylvia Baca has written a journal to help document the daily care they give their loved one. It's $25, with all profits going to support the programs of the IMF..

Sarah Klein's Bracelets

Sterling Bracelets by Sarah Klein
Sarah Klein's father, Benson, was diagnosed with myeloma in 1998, and has been in remission for 8 years.
Sarah wants to give back to the IMF in her own creative way and has designed two special bracelets made up of semi-precious healing stones. A portion of the proceeds from the sale of these bracelets is being donated to the IMF.

IMF Christmas Cards With Original Jr. IMFer Art
Ten cards per box, five of each style.
Inside card reads: Warmest wishes for peace, love, health and happiness this Christmas and throughout the year.

Ribbon of Hope Ornament
Whether hanging on a holiday tree, a wall, or any other creative place you can think of, the IMF's Ribbon of Hope ornament will bring a message of hope to anyone you give it to.
Multiple Colors for Multiple Myeloma Keychains and Earrings
Bring rainbows of happiness, color and light into your loved ones' lives with an IMF keychain or Swarovski crystal earrings.

Arbonne Cosmetics
Jo Marie Gray is donating her new-client commissions from the sale of Arbonne Cosmetics to the Chris Hollyer Research Fund at the IMF.
IMF Logo Items
Let the world know that you support the groundbreaking research and innovative patient support programs of the IMF with a hat or shirt or bracelets!
See more exciting ways to help the IMF continue its important work in education, support and research.

ITEMS OF INTEREST

The National Cancer Institute (NCI), a federal agency that is part of the National Institutes of Health (NIH) and the George Washington School of Public Health, would like to talk to women who are providing care for a family member or friend with cancer. They’d like to learn about your caregiving experience and how you have coped. If you are:

  • Female
  • African American
  • Between the ages of 31 and 80
  • Currently providing care for someone over the age of 20 with cancer, OR you provided care for someone over the age of 20 with cancer at end-of-life within the last year

Call them toll-free at 1-888-249-0029 (Monday to Friday, 9am-5pm EDT)

They will ask you some questions about yourself and your caregiving experience. Participating in this study involves a total of 15-20 minutes by phone. If they qualify, eligible participants may be asked to provide additional information about their caregiving experiences in a follow-up telephone interview that will last approximately 45-60 minutes.


Help for Underinsured Myeloma Patients
Thanks to the advocacy of the IMF, the Chronic Disease Fund has received an infusion of money to help them meet the needs of underinsured patients with multiple myeloma. The fund is designed to help patients with their insurance co-payments and/or their Medicare Part D 'doughnut holes.' Patients must qualify based on financial need. To speak with a representative of the Chronic Disease Fund, please call 877-968-7233, or contact them through their web site at cdfund.org.

Mensajero del Mieloma
La IMF quiere enviar información sobre el mieloma en español a todos los pacientes, familiares e interesados. Para suscribirse al correo electró nico (enviaremos cuatro ejemplares al año), por favor, env íe su dirección a mensajero@myeloma.org. ¡Gracias!


BANK ON A CURE®

International Staging System

NexProfiler
A tool to help understand the current status of the disease and the questions you should be asking.

Check out HealthTalk's Multiple Myeloma Education Network and Andrew Schorr's Patient Power.

Tell A Friend...
The Myeloma Minute is a great way to stay abreast of the latest developments within the myeloma community. We hope you'll share this information with friends, family members and physicians and encourage them to sign up for their own copy by forwarding this message. New users can register by clicking here.

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Official Newsletter of the IMF!

Many thanks to the supporters of The Myeloma Minute:
Celgene Corporation, Kyphon, Millennium Pharmaceuticals, Ortho Biotech, and The Binding Site.
Please call the hotline (800) 452-CURE (800-452-2873) or email TheIMF@myeloma.org if you have any questions.
Copyright 2002-2007. International Myeloma Foundation. All Rights Reserved.


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