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Sydney 2005: Anti-apoptotic Signalling in Multiple Myeloma Cells: Therapeutic Implications
By Laurence Catley
Dr. Catley presented in place of Dharminder Chauhan on therapeutic implications of anti-apoptotic signaling in MM cells. Defects in apoptotic signaling can lead to the development of drug resistance. In MM, loss of apoptotic response to chemotherapy results from the following reasons: genetic abnormalities, overexpression of anti-apoptotic proteins, MM cell binding to bone marrow and bone marrow stromal cells, and cytokines. Two major stress signaling pathways exist: extrinsic and intrinsic. Studies have shown that bortezomib induces apoptosis in both pathways suggesting that combining biochemical inhibitors of growth/survival signaling pathways with conventional anti-MM agents may enhance cell death. These data provide important information to guide future therapy directed at MM.

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