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Sydney 2005: Inhibition of Human Plasmacytoma Cell Growth by a Novel JAK Kinase Inhibitor
By Renate Burger
04.14.05
Dr. Burger offered a presentation on the inhibition of human plasmacytoma cell growth through a novel JAK kinase inhibitor. Protein tyrosine kinases of the JAK family have been associated with cytokine-like hormone receptors and regulate cell proliferation, survival, and differentiation. CB20 is a new small-molecule inhibitor developed and tested in MM cells. Results demonstrated the inhibition of MM cell growth and survival. Drug resistance was also avoided. Blocking these effects may prove to be valuable as a new therapeutic approach.


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