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Sydney 2005: Targeting the Insulin-Like Growth Factor-I Receptor (IGF-IR) in MM Cells ...
By Helena Jernberg-Wiklund
Dr. Helena Jernberg-Wiklund maintained this theme with her discussion on targeting the insulin-like growth factor-1 receptor (IGF-1R) in MM cells. The microenvironment network provides anti-apoptotic and proliferative signals through many molecular pathways. One of these signals is IGF-1R. Using a selective IGF-1R tyrosine kinase inhibitor to target IGF-1R in MM cells, Dr. Wiklund showed a reduction in survival and proliferation. Additionally, the function of critical signaling proteins was affected. In mouse model, survival was increased and tumor load reduced. Clinical trials to be initiated in solid tumors and MM in 2005.

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