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Sydney 2005:
Bcl-xl, Myc, and Mutant Ras Transgenic Mouse Models of Plasma Cell Malignancies
By Brian Van Ness, MD
Dr. Van Ness introduced the topic of mouse models of plasma cell malignancies. The approach used was to genetically engineer mice by identifying novel regulators, to assess the involvement of those regulators in stages of disease, and then to develop new mouse models. Notably, mice get hyperproliferative disease but do not develop tumors. Looking to the future, goals include developing mouse plasma cell tumor panels to show genetic heterogeneity, defining protein and gene expression profiles to link these data to human profiles, defining genetic modifications with a specific model system (lenti viral infection) to explore the effects of adding and blocking expression of genes, and identifying therapeutic responses.

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