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Sydney 2005: In MM Cells, Birn Pro-Apoptotic Functionis Neutralized Thru Endogenous Mcl-1/Birn ...
By Martine Amiot, MD
Dr. Amiot put forward a discussion on IL-6, a major MM factor that induces activation of multiple cell survival pathways. Dr. Amiot’s studies found 3 major isoforms that are expressed in MM cell lines. These isoforms are also negatively regulated by IL-6. Dr. Amiot proposed that disruption of cell interactions may present a novel therapeutic approach in the treatment of MM.

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