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Sydney 2005:
AKT in MM: Therapeutic Implications
By Alan Lichtenstein, MD
Dr. Lichtenstein discussed the therapeutic implications of the AKT kinase in MM. AKT has been known to prevent death in MM cells, however, Dr. Lichenstein hopes that with certain treatments, this action may be turned against tumor cells. With a preliminary review of the molecular mechanism activating AKT it was shown that AKT inhibits proliferation. With further study, findings showed high AKT activity sensitizes MM cells to certain inhibitors. Dr. Lichenstein hopes that future trials will be designed to evaluate pre-treatment AKT as a marker of treatment response.

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