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Sydney 2005:
Role of the IGF-1/IGF-1 Receptor Pathway in the 5TMM Experimental Mouse Model
By Karin Vanderkerken, MD
Dr. Vanderkerken continued discussions on the role of IGF-1/IGF-1 receptor pathway in the experimental mouse model. IGF-1 induces migration of 5TMM cells that are mediated by the P13K pathway. IGF-1 has also been found to induce DNA synthesis and VEGF secretion. Dr. Vanderkerken’s data demonstrated the relevance of receptor pathways in the pathobiology of MM and showed the potential for utilizing receptor pathways in future therapies for the treatment of MM.

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