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Sydney 2005:
Bone Marrow Homing of MM Cell
By Ivan Van Riet, MD
Dr. Van Riet shared Dr. Benjamin Van Camp’s presentation. MM cells are known to be restricted to the bone marrow (BM). Through studies, he and his colleagues evaluated cell lines from mouse models and reviewed the mechanism of action of homing to MM cells. Further studies revealed that endothelial cells help MM to migrate and concluded that homing of MM cells to BM is a complex process that involves multiple molecular pathways. By targeting these pathways, disease evolution may be affected leading to an emerging therapeutic tool with future extensive studies in human subjects.

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