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Sydney 2005:
MIP-1 May Cause Reciprocal of Osteoclast and Dendritic Cell Diff. from Monocytes
By Toshihiro Hashimoto, MD
04.13.05
Dr. Hashimoto presented results of studies looking at the ability of macrophage inhibiting protein (MIP)- 1a and ß and MM cells to affect osteoclasts (OC) and dendritic cells (DC). Results suggest that MIP-1 has a role in the formation and function of monocyte-derived OC. Additional data suggest that MIP-1 may be critical to OC cell lineage, maturation, activation, and to inhibition of DC maturation. Consequently, MM cells may be involved in the mechanism that affects bone resorption.


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