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Sydney 2005:
MIP-1 May Cause Reciprocal of Osteoclast and Dendritic Cell Diff. from Monocytes
By Toshihiro Hashimoto, MD
Dr. Hashimoto presented results of studies looking at the ability of macrophage inhibiting protein (MIP)- 1a and ß and MM cells to affect osteoclasts (OC) and dendritic cells (DC). Results suggest that MIP-1 has a role in the formation and function of monocyte-derived OC. Additional data suggest that MIP-1 may be critical to OC cell lineage, maturation, activation, and to inhibition of DC maturation. Consequently, MM cells may be involved in the mechanism that affects bone resorption.

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