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Sydney 2005:
RANK and MIP-1alpha in MM: Clinical Implications
By Evangelos Terpos, MD
04.13.05
Dr. Terpos opened his presentation by reviewing that bone disease is one of the most common presentations of MM. Osteoclast activity is induced by cytokines and osteoclast activation is important for MM cell survival. Specific signaling pathways (RANKL) and molecules that interact with those pathways (OPG) may work together to inhibit osteoclast differentiation. Dr. Terpos discussed the relationship between the probability of survival and expression of RANKL/OPG in MM. He closed his discussion suggesting that specific pathways are important for myeloma survival and for the pathogensis of bone disease, and that molecules in these pathways may serve as targets for antimyeloma agents.


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