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Sydney 2005: Microarray Exp. Profiling Indicates Upreg. of Ribosomal Machinery in del(13)-Neg Clone
By Friedrich Cremer, MD
Dr. Cremer discussed the biological functions of specific predictor genes that are related to protein and DNA metabolism, cell growth and maintenance, cell communication, response to external stimuli, and cell death. He noted that overexpression of specific genes is related to cell growth, disease progression, and drug resistance. There is a possible pathogenetic role of the upregulation of specific genes (predictor genes, most frequently ribosomal protein genes) since these proteins are found in some cancers and malignant processes.In other tumors (eg, CLL, ovarian cancer), no correlation between over-expression of these proteins and proliferation is noted.

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