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Sydney 2005: Molecular Mechanism Involved in Homing and Migration of Plasma Cells to the Bone Marrow
By Irene Ghobrial, MD
Dr. Ghobrial discussed the molecular mechanism involved in homing and migration of plasma cells to the bone marrow. The therapeutic implication is the delay or prevention of disease progression in early MM. By mobilizing MM cells from BM to the peripheral blood (PB), the cells may become a target for chemotherapeutic agents; while the cells are in the BM, they are protected. Dr. Ghobrial proposed a model homing plasma cells into and out of the BM by inducing growth factors to push the myeloma cells into the vascular space and allowing recirculation. In the future, other specific pathways of migration and the molecules that trigger the migration may be targets for drug development.

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