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Sydney 2005: Targeting of VEGF and PDGF Signaling by Receptor Tyrosine Kinase Inhibitors Impairs...
By Ivan Van Riet, MD
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04.12.05 |
Dr. Van Riet discussed the molecules that could control disease development, specifically discussing VEGF and PDGF signaling by receptor tyrosine kinase inhibitors (RTKI). In a model system, Dr. Van Riet showed the ability of MM cells to stimulate angiogenesis and increase microvessel density (MVD). RTKI impaired myeloma cell-mediated blood vessel formation in an in vitro system. Using an in vivo mouse model, administration of RTIs resulted in a significant reduction in MVD. These data suggest that RTKIs may be able to inhibit microvessel formation.
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