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Sydney 2005:
Osteoblast Function in Myeloma (endothelin 1, osteoblast proteosome)
By Greg Mundy, MD

Dr. Mundy discussed osteoblast function in MM. Myeloma cells are found in bone marrow and through the course of MM myeloma cells influence bone destruction by inhibiting formation of bone and increasing resorption of bone. Velcade is successful in the treatment of myeloma, causing the myeloma cells to behave in a more normal manner. Mundy and associates suggest that Velcade may also be helpful in stimulating bone formation, thus possibly acting as a treatment for bone disease associated with myeloma. They are conducting experiments to clarify if Velcade can both limit tumor burden and repair bone destruction.

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