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Sydney 2005:
Pathogenesis of Myeloma Bone Disease
By G. David Roodman, MD

Dr. Roodman presented on the pathogenesis of bone disease in MM. Bone lesions occur in up to 80% of MM patients; bone fractures occur in 60% of MM patients. MM patients also experience bone pain related to destruction of their bone tissue. Roodman and associates show that myeloma cells are involved in both the destruction of bone tissue and in the prevention of the repair of bone tissue. Patients with MM produce molecules that stimulate osteoclasts (cells that break down bone tissue) and inhibit osteoblasts (cells that build bone tissue). Combined, these effects result in the severe bone disease that MM patients experience.

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