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Sydney 2005:
Normal Plasma Cell Development and Pathogenesis of MGUS and MM
By Suhinder S. Sahota, MD
Dr. Sahota reviewed normal plasma cell development and pathology of MGUS and MM. In order to understand MM, one must understand the origin of the plasma cells causing MM. Sahota and colleagues focused on analyzing the regions of immunoglobulin molecules present in MM and MGUS to answer some of these questions. Their research showed that normal plasma cells produce different forms of immunoglobulins G and A in response to signals from the bone marrow. In smoldering MM plasma cells, some immunoglobulins are produced consistently. In MGUS, these same immunoglobulins are produced in a variable manner and Sahota suggests that these variable immunoglobulins are linked to the development of MM.

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