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Sydney 2005:
Is Thalidomide First Line Therapy?
By Donna Weber, MD
Dr. Weber posed the question, "Is Thalidomide First-line Therapy?." She presented an overview of several trials utilizing combination therapy of thalidomide in untreated MM. The results of these trials, at this time, showed a clear superiority for using thalidomide, but also the increased risk of thrombosis and neuropathy. Several more trials have ensued using combination thalidomide, but with the use of prophylactic anticoagulants. Dr. Weber indicated that further research will evaluate the use of newer agents and lower doses of thalidomide to provide a greater response with fewer effects.

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