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Sydney 2005:
Alternative Gene Splicing in Myeloma; Aberrant Splicing of Hyalur.
By Linda Pilarski, MD
Dr. Pilarski presented findings on alternative gene splicing in myeloma hyaloronan synthetase 1 (HAS1) synthesizes hyaluronan (HA), an extracellular matrix protein that is involved in cell signaling and in malignant progression. HAS1 is the first blood born prognostic marker for malignant cells and predicts poor outcomes in MM patients. Various forms of HAS1 may be produced in cells and these various forms have strong impact on clinical outcomes. Pilarski and associates report that abnormal forms of HAS1 may predispose patients to disease or to the development of progressive MM and short survival.

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