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Sydney 2005:
Clinical and Biologic Implications of Genomics in Myeloma
By Rafael Fonseca, MD
Dr. Fonseca provided an overview of the integration of genetics in a comprehensive pathogenesis model for MM. Different pathways of pathogenesis follow from MGUS to MM and the progression from MGUS to MM likely follow specific pathways dependent on the genetic composition of the MGUS cells. In rapidly progressing cases, long term bone destruction does not have time to develop. The susceptibility for individuals to develop MGUS and MM is not clear but may be related in part to racial differences linked to the ability to repair double stranded DNA. Fonseca and colleagues suggest that genetics must be incorporated into the development of targeted therapies. Such an approach would identify the treatment regimen most likely to succeed for individual patients.

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