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Sydney 2005:
Cross-talks Between Plasma Cells and the Microenvironment: Triggering and Targeting
By Federico Caligaris-Cappio, MD
Dr. Caligaris-Cappio reviewed the role of hypoxia in the bone marrow microenvironment in his discussion of cross-talk between plasma cells and the microenvironment. Plasma cells from patients with MM express statistically significantly more hypoxic factor 1-alpha (HF1) than do plasma cells from MGUS patients. Hypoxia also turns on an angiogenic switch; plasma cells in MM are hypoxic and so are producing angiogenic factors. Notably, hypoxia causes a large number of cells to proliferate. Strong interactions between MM cells and the bone marrow icroenvironment results in signals being delivered to developing tumor cells. These interactions may serve as a new target for developing therapies. Similarly, the potential for T cells to act in the bone marrow microenvironment of MM may lead to the potential to develop an immunotherapeutic therapy based on T-cells recognizing naïve tumor cells.

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