Myeloma Minute - October 9, 2004
- Nobel Prize winners explained "protein disposal"
Two Israelis and an American won the Nobel Prize in Chemistry for the discovery of ubiquitin-mediated protein degradation, the method by which cells tag proteins that are defective or have outlived their usefulness and direct them to the cellular machinery that grinds them up into reusable parts. One drug that works in the ubiquitin pathway is in clinical use bortezomib, sold as Velcade, for myeloma. (from The Seattle Times)
- Scottish cancer patients hope Velcade will be approved by the Scottish Medicines Consortium
Campaigners for myeloma awareness are hoping that the SMC will approve the drug, but they are taking nothing for granted. "For myeloma patients, this drug is a really significant development," said Eric Low, executive director of the International Myeloma Foundation (UK), based in Edinburgh.
- When Doctors Go Off-Label
Off-label marketing has been an increasingly important issue in the drug industry. It is common in oncology, where specialists often respond to new data before regulators can review it. For instance, most use of Celgene's Thalomid is off-label. The drug is used to treat multiple myeloma, but has never been approved for that. (from Forbes)
- A few tickets are still available for the 14th Anniversary Ribbon of Hope Making A World of Difference Gala on November 6 at the Millennium Biltmore Hotel in Los Angeles. Honoring our own Dr. Brian Durie, this promises to be the biggest and best Gala ever. Awards for their dedication to improving the lives of myeloma patients will be given to Karen Talmadge of Kyphon, The Los Angeles MM Support Group, Captain Fred Gloor, and David J. Brown. A beautiful hotel, a gourmet meal, and some of the most awesome auction items ever assembled make for one fabulous night. And the money you pay to have a wonderful time will help the IMF fund its educational and advocacy programs and fund research initiatives. Call 800-452-2873 ext 222 for information.
WHAT'S NEW IN RESEARCH
- VELCADE® trials
- THALOMID® trials
- TRISENOX trials
- REVLIMID trials
- Phase I/II Study of Atiprimod
MD Anderson Cancer Center, Houston, TX, Moshe Talpaz, MD, tel 713-792-3522
Dana Farber Cancer Institute, Boston, MA, Nikhil Munshi, MD, tel 617-632-2681
- Randomized Phase III Study of CC-5013 plus Dexamethasone versus CC-5013 plus Low Dose Dexamethasone in Multiple Myeloma with Thalidomide plus Dexamethasone Salvage Therapy for non-Responders
Eastern Cooperative Oncology Group E4A03
For more information, the Myeloma Matrix has a current list of all myeloma trials from pre-clinical to recently FDA approved. If you would like to browse trials currently open for enrollment, visit the Clinical Trials page of the IMF web site. Among the links, you will find CenterWatch and EmergingMed. The IMF has entered into partnerships with them to assist you in matching trials to your particular patient profile (i.e., stage of disease, previous treatment, how well you are able to carry out the activities of daily living, etc.) and by doing so, increase your chances of being eligible. You can also learn more about clinical trials by reviewing materials from the National Cancer Institute.
If you live near any these local fundraisers, why not go on over? They are always fun, and the money raised helps the IMF help others.
FUNdraising Made Easy
Suzanne Battaglia can help you plan your fundraiser, so please write, call or email (SBattaglia@myeloma.org) so that you can get on our Calendar of Events!
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