- ASH 2003: An Avalanche of New Information
What does it all mean, and where do we go from here? IMF Chairman Dr. Brian Durie sorts it all out for us.
- In Search Of The Myeloma Stem Cell: A Special Report
At this year’s ASH meeting, the Unknown Patient was privileged to meet a team of young investigators pursuing an ambitious and innovative objective--finding the myeloma stem cell.
- More ASH News
- Good News Halts Velcade Phase III Trial
Trial halted because so many patients responded favorably that Millennium said it would be unethical to deny the treatment to the study's control group. (from the Boston Globe)
- Thalidomide Pharmion Approved in New Zealand for Treatment of Myeloma After Failure of Standard Therapies
New Zealand is only the second country besides the United States to approve the drug.
- McCarty Cancer Foundation and the Van Andel Institute have formed a collaboration to find a cure for myeloma. Craig McCarty, father of Detroit Red Wings Star, Darren McCarty, died from myeloma. The McCarty Cancer Foundation has endowed a $3 million dollar multiple myeloma lab at the Van Andel Institute.
- Proteasome inhibitor plus thalidomide treats patients with multiple myeloma.
Promising preliminary Phase I/II study results using VELCADE(TM) (bortezomib) in combination with thalidomide for the treatment of patients with advanced stage multiple myeloma that have failed several prior treatments. More than 20 percent of patients achieved a complete or near complete response and overall more than 50 percent patients achieved at least a partial response.
All about Proteasome inhibitors from Millennium's site. Includes an animated video.
What's New in Myeloma Research:
- Dendritic cell-based immunotherapy in multiple myeloma
Researchers discuss myeloma antigens and antigen-specific immune responses, the capacity of DCs to present myeloma antigens and induce cytotoxic T-cell responses, and clinical experience of DC vaccination in myeloma patients.
- Farnesyl transferase (FTase) inhibitors may be an effective treatment for of multiple myeloma.
Preclinical data provide evidence that FTase inhibitors may be an effective therapeutic modality for the treatment of multiple myeloma.
- Insulin-like growth factor I induces migration and invasion of human multiple myeloma cells
Ya-Wei Qiang, Lei Yao, Giovanna Tosato and Stuart Rudikoff
The identification of IGF-I as both a proliferative and migratory factor provides a rational basis for the development of targeted therapeutic strategies directed at IGF-I in the treatment of MM.
- Myeloma is on the move
An Inside Blood article by John D. Shaughnessy, Jr discussing the research mentioned above.
- Treatment of multiple myeloma
IMF Scientific Advisor Bart Barlogie, John Shaughnessy, Guido Tricot, Joth Jacobson, Maurizio Zangari, Elias Anaissie, Ron Walker, and John Crowley
A Blood review article by the team in Arkansas.
- Interleukin-6-dependent gene expression profiles in multiple myeloma INA-6 cells reveal a Bcl-2 family-independent survival pathway closely associated with Stat3 activation
Katja Brocke-Heidrich, Antje K. Kretzschmar, Gabriele Pfeifer, Christian Henze, Dennis Loffler, Dirk Koczan, Hans-Jurgen Thiesen, Renate Burger, Martin Gramatzki, and Friedemann Horn
Research provides evidence for the existence of an as yet unknown Stat3-dependent survival pathway in myeloma cells.
- Telomerase inhibition with an oligonucleotide telomerase template antagonist: in vitro and in vivo studies in multiple myeloma and lymphoma
Eunice S. Wang, Kaida Wu, Allison C. Chin, Selina Chen-Kiang, Krisztina Pongracz, Sergei Gryaznov, and Malcolm A. S. Moore
Data demonstrate that telomerase is important for the replication of mature B-cell neoplasia by stabilizing short telomeres, and suggest that telomerase inhibition represents a novel therapeutic approach to MM.
What's New in Clinical Trials:
(Drugs listed In alphabetical order)
- New Drug, Aplidin, in the Matrix Pipeline
- SAHA (suberoylanilide hydroxamic acid)
- Phase I trial of histone deacetylase inhibitor for treatment of advanced multiple myeloma.
- Cancer Trials Support Unit: A Web Based System That Offers Efficient and Effective Tools for Clinical Trials Management.
The Cancer Trials Support Unit (CTSU) is an NCI funded program to facilitate participation (by both patients and physicians) in phase III NCI sponsored Cancer treatment trials.
If you would like to browse trials currently open for enrollment, visit the Clinical Trials page of the IMF web site. Among the links, you will find CenterWatch and EmergingMed. The IMF has entered into partnerships with them to assist you in matching trials to your particular patient profile (i.e., stage of disease, previous treatment, how well you are able to carry out the activities of daily living, etc.) and by doing so, increase your chances of being eligible. You can also learn more about clinical trials by reviewing materials from the National Cancer Institute.
Quality of Life Update:
Upcoming Seminars and Conferences:
FUNdraising Made Easy
You know you want to do something, but deciding on what to do can be confusing. The IMF can help. This year, our members really rallied 'round the cause, picked up the gauntlet, and raised a lot of money for myeloma research and programs.
We are already getting calls from new members who want to join in the effort and hold an event in 2004. Suzanne Battaglia is waiting for your call. She is here to help you plan and execute your event, so please write, call or email (SBattaglia@myeloma.org) so that you can get on our Calendar of Events!
See what you can do in your community to help further the goal of finding the cure!
Items of Interest:
- Understanding Thalidomide Therapy on the Web
Read it on the web or download and print the PDF document. Available in English, Spanish, French, German, and Italian.
- The National Cancer Institute (NCI) Office of Education and Special Initiatives is looking for patients, family caregivers, and physicians who are interested in participating in telephone focus groups and in-depth interviews. Payment will be provided to all participants.
- BANK ON A CURE®
BANK ON A CURE is an innovative and powerful concept designed to establish a method to find new treatments for multiple myeloma and other related diseases as well as the possibility of new cures, while customizing care for current patients.
- Myeloma Matrix
The Myeloma Matrix provides updated information about drugs beginning with pre-clinical developments and tracks drugs as they proceed through Phases I – III of clinical trials, drugs that have been FDA approved, and information on trials that are being conducted by NCI- sponsored cooperative groups as well as other myeloma study groups. The online version is updated regularly. If you would like to have a printed copy, call the toll-free hotline (800) 452-2873.
- International Prognostic Index
The International Myeloma Foundation is proud to sponsor the International Prognostic Index (IPI) Classification for Multiple Myeloma. Nearly twenty myeloma institutions from around the world are collaborating to create an updated staging system for multiple myeloma.
- NexCura Cancer Profiler
The Cancer Profiler is a free service (no hidden fees or charges). Its tools provide you with information specific to your cancer diagnosis to help you make more informed treatment decisions along with your physician.
- Expert Opinions on Multiple Myeloma
A multimedia, CME-accredited program for physicians with the chance to see world-renowned myeloma specialists sharing their knowledge, discussing treatment choices, and comparing their perspectives on controversial issues in multiple myeloma and related diseases.
- Myeloma At The Movies
It has been our goal to bring our Patient & Family Seminars to people around the country who might not be able to attend an actual meeting, so we have set up a video lending library.
- HealthTalk's Multiple Myeloma Education Network
The latest interview is Dr. Durie interviewing Dr. Rajkumar about promising IMF Clinical Trials.
Be Part of the Cure!
Many of the internet's most popular merchants will donate a portion of your purchases to the IMF if you enter their sites using the links on our Shop For The IMF page. You can also use the special shortcut URLs listed below:
So, Be Part of the Cure by using these links to the same get great service and low prices you're used to while helping support the IMF!
Help Us Help Others...
As a non-profit organization, the IMF is completely dependent on the support of our members. Please consider showing your support by making a tax-deductible donation today. Donations in honor of a friend or family member make great gifts and are a wonderful way to celebrate a special occasion. You can donate online or by calling the IMF at (800) 452-CURE. We sincerely thank you for your support.
Tell A Friend...
The Myeloma Minute is a great way to stay abreast of the latest developments within the myeloma community. We hope you'll share this information with friends, family members and physicians and encourage them to sign up for their own copy by forwarding this message. New users can register by clicking here.