What's New in Myeloma Research:
- A Phase 2 Study of Bortezomib in Relapsed, Refractory Myeloma
IMF Scientific Advisors Bart Barlogie, M.D., Ph.D., James Berenson, M.D., Seema Singhal, M.D., Sundar Jagannath, M.D., Raymond Alexanian, M.D., and Paul G. Richardson, M.D., David Irwin, M.D., S. Vincent Rajkumar, M.D., Gordan Srkalovic, M.D., Melissa Alsina, M.D., David Siegel, M.D., Robert Z. Orlowski, M.D., David Kuter, M.D., Ph.D., Steven A. Limentani, M.D., Stephanie Lee, M.D., Teru Hideshima, M.D., Ph.D., Dixie-Lee Esseltine, M.D., Michael Kauffman, M.D., Ph.D., Julian Adams, Ph.D., David P. Schenkein, M.D., and Kenneth C. Anderson, M.D.
See Velcade article above.
- Dual effects of macrophage inflammatory protein-1 on osteolysis and tumor burden in the murine 5TGM1 model of myeloma bone disease
Babatunde O. Oyajobi, Giovanni Franchin, Paul J. Williams, Donna Pulkrabek, Anjana Gupta, Steve Munoz, Barry Grubbs, Ming Zhao, Di Chen, Barbara Sherry, and IMF Scientific Advisor Gregory R. Mundy
Recent data have implicated macrophage inflammatory protein-1 (MIP-1) in multiple myeloma -associated osteolysis. However, it is unclear whether the chemokine's effects are direct, to enhance osteolysis, or indirect and mediated through a reduction in tumor burden, or both.
- Gene profiling of a myeloma cell line reveals similarities and unique signatures among IL-6 response, N-ras activating mutations and co-culture with bone marrow stromal cells
Paula A Croonquist, Michael A Linden, Fangyi Zhao, and IMF Scientific Advisor Brian G Van Ness
Researchers demonstrated gene expression patterns in myeloma cells that distinguish an intrinsic genetic transformation event, and patterns derived from both soluble factors and cell contacts in the bone marrow microenvironment.
- Reovirus oncolysis as a novel purging strategy for autologous stem cell transplantation
Chandini M. Thirukkumaran, Joanne M. Luider, Douglas A. Stewart, Tina Cheng, Sasha M. Lupichuk, Michael J. Nodwell, James A. Russell, Iwona A. Auer, and Donald G. Morris
Ex vivo use of an unattenuated oncolytic virus is an attractive purging strategy for autologous stem cell transplantations.
- Polymorphic variation in GSTP1 modulates outcome following therapy for multiple myeloma
Ranjit K Dasgupta, Peter J Adamson, Faith E Davies, Sara Rollinson, Philippa L Roddam, A J Ashcroft, Ann M Dring, James A Fenton, J A Child, James M Allan, and Gareth J Morgan
Glutathione S-transferase P1 (GSTP1) is a phase II drug metabolism enzyme involved in the metabolism and detoxification of a range of chemotherapeutic agents.
What's New in Clinical Trials:
- New sites added to Revimid study list as of 6/20/03
- Myeloma Matrix (updated 6/25/03)
The Myeloma Matrix provides updated information about drugs beginning with pre-clinical developments and tracks drugs as they proceed through Phases I – III of clinical trials, drugs that have been FDA approved, and information on trials that are being conducted by NCI- sponsored cooperative groups as well as other myeloma study groups. The online version is updated regularly. If you would like to have a printed copy, call the toll-free hotline (800) 452-2873.
If you would like to browse trials currently open for enrollment, visit the Clinical Trials page of the IMF web site. Among the links, you will find CenterWatch and EmergingMed. The IMF has entered into partnerships with them to assist you in matching trials to your particular patient profile (i.e., stage of disease, previous treatment, how well you are able to carry out the activities of daily living, etc.) and by doing so, increase your chances of being eligible. You can also learn more about clinical trials by reviewing material from the National Cancer Institute.
Quality of Life Update:
- Researchers in WHAT'S NEWS above reported that anemia is often undertreated in myeloma patients. So we thought we would take a look at this common symptom of cancer and side effect of cancer treatment. Here is some background information on anemia:
CancerSource's Topic Zone on anemia is a good place to start, featuring basic explanations of what it is and how to manage it.
- Anemia & Cancer
"While fatigue is primary symptom of anemia in cancer patients, anemia can also cause a range of other symptoms..." (a PDF document from the National Anemia Action Council)
- New category added to "Events" section on IMF web site for local support group activities
Planning educational events or meetings? Increase attendance and participation by using the IMF's web site to help get the word out to interested parties in your area. Scroll down to the bottom of the page and see what other support groups are doing.
If you are interested in joining a support group, use the IMF's worldwide support group directory to find one that meets near you. You can also join our online support group.
If you have a topic of particular interest that you would like us to feature, if you are starting a support group, or if you are in a support group that is doing something to make a real difference in the lives of mutiple myeloma patients and their families and friends, let us know.
Upcoming Seminars and Conferences:
FUNdraising Made Easy
You know you want to do something, but deciding on what to do can be confusing. The IMF can help.
||Mile High March for Myeloma
August 16, 2003
Lake Arrowhead, CA
- Robert Kyle Lifetime Achievement Awards Dinner
August 2, 2003
The International Myeloma Foundation is proud to present its first Robert A. Kyle Lifetime Achievement Award to Robert A. Kyle, M.D., Professor of Medicine & Laboratory Medicine, Mayo Clinic, in recognition for his outstanding life work, clinically and in research, in the field of myeloma. The award will be presented in subsequent years to honor other professionals for their work in the field.
- Ribbon of Hope Making A World of Difference Anniversary Gala
October 4, 2003
Paul Allen's Experience Music Project Museum in Seattle, WA
The evening promises to be the best ever, both creatively and financially! The EMP is Seattle's most unique architectural wonder. The Frank O. Gehry-designed building houses a new interactive museum that combines performance space, technology and revolutionary architecture in a facility created to celebrate the heritage and anticipate the future of American popular music.
- Third Multiple Myeloma Quilt of Courage is Online
The third quilt is finished and on the web. Like the two before it, it is both beautiful and moving. Take a look for yourself.
Those of you who have ordered quilt squares for the 4th quilt and have not yet returned them, please do so at your earliest convenience. We cannot put the quilt together and up on the web site until all the squares are returned. If you are not able to finish your square, please advise Suzanne at SuzanneBattaglia@myeloma.org so that she can give members on the waiting list the space she is holding for you.
Items of Interest:
- BANK ON A CURE™
BANK ON A CURE™ is an innovative and powerful concept designed to establish a method to find new treatments for multiple myeloma and other related diseases as well as the possibility of new cures, while customizing care for current patients.
- International Prognostic Index
The International Myeloma Foundation is proud to sponsor the International Prognostic Index (IPI) Classification for Multiple Myeloma. Nearly twenty myeloma institutions from around the world are collaborating to create an updated staging system for multiple myeloma.
- NexCura Cancer Profiler
The Cancer Profiler is a free service (no hidden fees or charges). Its tools provide you with information specific to your cancer diagnosis to help you make more informed treatment decisions along with your physician.
- Expert Opinions on Multiple Myeloma
A multimedia, CME-accredited program for physicians with the chance to see world-renowned myeloma specialists sharing their knowledge, discussing treatment choices, and comparing their perspectives on controversial issues in multiple myeloma and related diseases.
An exciting new way for myeloma patients to get involved at patient seminars.
- Myeloma At The Movies
It has been our goal to bring our Patient & Family Seminars to people around the country who might not be able to attend an actual meeting, so we have set up a video lending library. New tapes have recently been added from the Seattle Patient & Family Seminar.
Shop for the Cure!
Many of the internet's most popular merchants will donate a portion of your purchases to the IMF if you enter their sites using the links on our Shop For The Cure page. You can also use the special shortcut URLs listed below:
So, Shop For The Cure by using these links to the same get great service and low prices you're used to while helping support the IMF!
Help Us Help Others...
As a non-profit organization, the IMF is completely dependent on the support of our members. Please consider showing your support by making a tax-deductible donation today. Donations in honor of a friend or family member make great gifts and are a wonderful way to celebrate a special occasion. You can donate online or by calling the IMF at (800) 452-CURE. We sincerely thank you for your support.
Tell A Friend...
The Myeloma Minute is a great way to stay abreast of the latest developments within the myeloma community. We hope you'll share this information with friends, family members and physicians and encourage them to sign up for their own copy by forwarding this message. New users can register by clicking here.